Preparation method of ornithine aspartate

A technology of ornithine aspartate and ornithine hydrochloride, applied in the field of preparation of ornithine aspartate, can solve the problems of high cost, large pollution, and easy generation of impurities

Inactive Publication Date: 2013-03-13
肖文辉 +1
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Problems solved by technology

[0002] Aspartic acid ornithine is a medicine for treating liver diseases, which is widely used clinically. However, at present, the preparation method of aspartic acid ornithine is mainly to use ornithine hydrochloride as raw material, and use ion exchange resin to remove Remove chlorine ions

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  • Preparation method of ornithine aspartate
  • Preparation method of ornithine aspartate

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example 1

[0028] (1) Desalination of L-ornithine hydrochloride

[0029] Take 168g of L-ornithine hydrochloride, add 500ml of water to dissolve, add 40% sodium hydroxide to adjust the pH value to 11.0 (L-ornithine isoelectric point); add water to make the volume to 1000ml, in the two-stage recovery chamber of the electroosmosis device Add 0.1 mol / L hydrochloric acid and sodium hydroxide solution to each, adjust the voltage to 20 volts, and then pass the above-mentioned L-ornithine solution through the electrodialyzer at a rate of 20 ml per minute. L silver nitrate solution to check whether the chloride ions have been removed cleanly, collect the chloride-free solution for the next step.

[0030] (2) Preparation of ornithine aspartate

[0031] Take the above desalted ornithine solution and add 132g of L-aspartic acid, adjust the pH to 5.0-7.0, until insoluble matter appears in the solution (excess aspartic acid), filter to remove excess aspartic acid , The solution was decolorized with 1.0% ac...

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Abstract

As a drug for treatment of liver diseases, ornithine aspartate has very wide application clinically. However, existing ornithine aspartate preparation methods consist of: taking ornithine hydrochloride as the raw material, using ion exchange resin to remove chloride ions, then employing ammonia water to conduct elution, carrying out heating to remove ammonia, and adding aspartic acid to perform salification, and have the disadvantages of great time consumption, high cost, large acid-base consumption, great pollution, instability of L-ornithine under an alkaline condition during heating for ammonia removing, and easy generation of impurities. The method provided in the invention includes: adopting ornithine hydrochloride as the starting material, employing an electrodialysis method and making use of the principle that charged ions move under a current function to remove chloride ions in the ornithine hydrochloride, adding aspartic acid to perform salification, and conducting refining with methanol or ethanol. The method not only guarantees the stability of L-ornithine, has the characteristics of simplicity, practicability, and low cost, but also substantially alleviates the environmental protection pressure due to less acid-base consumption, and improves the production capability, thus being suitable for scale-up production.

Description

1. Technical Field [0001] The invention belongs to a preparation method of ornithine aspartate for treating liver disease. 2. Background technology [0002] Ornithine aspartate is a drug for the treatment of liver diseases and has been widely used in clinical practice. However, the current preparation method of ornithine aspartate is mainly based on ornithine hydrochloride as raw material, and ion exchange resin The chloride ion is removed, and then eluted with ammonia water, and then heated to remove ammonia, and then added aspartic acid to form a salt. This method is time-consuming and costly. It uses a lot of acid and alkali, and the pollution is large. When heated to remove ammonia, L-bird Amino acid is unstable under alkaline conditions and easily produces impurities. This method uses ornithine hydrochloride as the starting material, adopts electrodialysis method, uses the principle of charged ions to move under the action of electric current to remove chloride ions in orni...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C227/16
Inventor 肖文辉熊祥珍
Owner 肖文辉
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