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Curcumin particle suspension used for intramuscular injection and hypodermic injection, preparation method and application

A technology for subcutaneous injection and curcumin, applied in the field of curcumin sustained-release microparticle suspension for intramuscular or subcutaneous injection and its preparation, can solve the problems of increasing the difficulty of the preparation process, achieve slow release, stable quality, and meet production needs Effect

Inactive Publication Date: 2013-05-01
CHANGZHOU TARGET MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If no solubilization or co-solvent is used in the suspension, the safety of clinical medication can be fully guaranteed, but it also increases the difficulty of the preparation process

Method used

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  • Curcumin particle suspension used for intramuscular injection and hypodermic injection, preparation method and application
  • Curcumin particle suspension used for intramuscular injection and hypodermic injection, preparation method and application
  • Curcumin particle suspension used for intramuscular injection and hypodermic injection, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: Weigh 10g of curcumin raw material, add 50ml of water for injection, put in a wet grinding machine (Mini-Easy nano-grinding equipment), circulate and grind for 1h, heat and sterilize, obtain curcumin microparticle suspension for injection, measure The average particle diameter is 1209nm. The measurement results of its particle size distribution are shown in figure 1 .

Embodiment 2

[0039] Example 2: Weigh 10 g of curcumin raw material, add 50 ml of deionized water, put it in a wet grinding machine (Mini-Easy nano grinding equipment), grind it in circulation for 2 hours, heat and sterilize, and prepare curcumin microparticle suspension for injection , The measured average particle size was 728nm.

Embodiment 3

[0040] Example 3: Weigh 10 g of curcumin raw material, add 50 ml of deionized water, put it in a wet grinding machine (Mini-Easy nano grinding equipment), grind for 3 hours in circulation, heat and sterilize, and prepare curcumin microparticle suspension for injection , The measured average particle size was 413nm.

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Abstract

The invention discloses a curcumin particle suspension having a slow release effect used for intramuscular injection and hypodermic injection, and a method for preparing the suspension used for injection. An auxiliary material of the curcumin particle suspension used for injection contains no solubilizer or cosolvent, the security is good; the curcumin particle suspension can reach slow release effect through hypodermic and intramuscular injection administration, the stability of the curcumin particle suspension is good, and the curcumin particle suspension can be used in industry.

Description

technical field [0001] The invention relates to a slow-release preparation of an insoluble natural product, in particular to a curcumin slow-release microparticle suspension for intramuscular or subcutaneous injection, a preparation method and application thereof. Background technique [0002] Curcumin (curcumin) is a polyphenolic compound extracted from the rhizomes of turmeric, curcuma, turmeric, etc. [0003] [0004] Pharmacological experiments show that curcumin has a variety of pharmacological effects, including anti-inflammatory, anti-cancer, anti-oxidation, kidney protection, inhibition of pulmonary fibrosis, inhibition of liver fibrosis, helping muscle damage repair, treatment of cataracts, anti-parasitic diseases, etc., especially Curcumin nanoformulations: a future nanomedicine forcancer.Drug Discov Today.2011 Sep 18. doi:10.1016 / j.drudis.2011.09.009]. Curcumin has a strong preventive effect on the three stages of tumor carcinogenesis, and is a natural tumor ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/122A61P3/00A61P9/00A61P25/00A61P35/00A61P35/02A61P37/02
Inventor 刘珂许卉初大丰邹晓丽郎跃武
Owner CHANGZHOU TARGET MEDICINE TECH CO LTD
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