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Enteric-coated positioning osmotic pump controlled release capsules containing sinomenine hydrochloride and preparation method of controlled release capsules

A technology of osmotic pump controlled release and sinomenine hydrochloride, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve problems such as gastric irritation and sinomenine hydrochloride enteric-coated preparations cannot be released at a constant rate. , to achieve the effect of long-lasting drug effect, stable curative effect and constant release

Pending Publication Date: 2019-03-01
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, provide a kind of enteric-coated and positioned-release sinomenine hydrochloride controlled-release capsules, solve the problem that the enteric-coated sinomenine hydrochloride preparation cannot be released at a constant rate, and the osmotic pump preparation is in the stomach. Technical problems such as gastric irritation caused by the release of the drug, so as to realize the intestinal controlled release of sinomenine hydrochloride, avoid the premature release of the drug in the stomach, which will affect the drug effect or produce side effects, and can maintain the blood drug concentration for a long time

Method used

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  • Enteric-coated positioning osmotic pump controlled release capsules containing sinomenine hydrochloride and preparation method of controlled release capsules
  • Enteric-coated positioning osmotic pump controlled release capsules containing sinomenine hydrochloride and preparation method of controlled release capsules
  • Enteric-coated positioning osmotic pump controlled release capsules containing sinomenine hydrochloride and preparation method of controlled release capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules

[0026] Capsule Shell Prescription:

[0027]

[0028]

[0029] Preparation Process:

[0030] Preparation of capsule shells:

[0031] (1) Preparation of capsule liquid: Since PEG is a water-soluble material, a certain amount of water is first added to dissolve it when preparing; stand still to remove air bubbles.

[0032] (2) Use the glue dipping process to dip in the glue. When dipping in the glue for a certain number of times, pull out the shell, cut, arrange, make a drug release hole on the top of the capsule cap, and seal the hole with enteric glue, that is, enteric-coated positioning osmotic pump control Release the capsule shell.

[0033] Preparation of sinomenine hydrochloride enteric-coated osmotic pump controlled-release capsules

[0034] (1) Precisely weigh the main drug and auxiliary material powders that have passed through an 80-mesh...

Embodiment 2

[0036] Example 2 Preparation of sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules

[0037] Capsule Shell Prescription:

[0038]

[0039]

[0040] Preparation Process:

[0041] The preparation of capsule shell is the same as example 1.

[0042] The preparation of sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules is the same as Example 1.

Embodiment 3

[0043] Example 3 Preparation of sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules

[0044] Capsule Shell Prescription:

[0045]

[0046]

[0047]

[0048] Preparation Process:

[0049] The preparation of capsule shell is the same as example 1.

[0050] The preparation of sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules is the same as Example 1.

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Abstract

The invention relates to enteric-coated positioning osmotic pump controlled release capsules containing sinomenine hydrochloride and a preparation method of the controlled release capsules. The capsules comprise enteric-coated positioning osmotic pump controlled release capsule shells and content contained in the capsule shells. The enteric-coated positioning osmotic pump controlled release capsule shells are prepared from cellulose acetate, an enteric-coated pore-foaming agent and a plasticizer, drug release holes are formed in the capsule shells and can be used for filling chemical drugs, traditional Chinese medicines and biological drugs, drug release rate can be controlled, and the effect of intestinal positioning release is realized. The content contains sinomenine hydrochloride powder, a penetration enhancer, a penetration promoting polymer and other pharmaceutical adjuvants. The enteric-coated positioning osmotic pump controlled release capsules can realize intestinal controlledrelease of sinomenine hydrochloride, are prepared with a simple process, have a low requirement for equipment, and are easy to operate and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to sinomenine hydrochloride enteric-coated positioning osmotic pump controlled-release capsules and a preparation method thereof. Background technique [0002] Sinomenine hydrochloride is the hydrochloride salt of sinomenine, the main active ingredient in the rhizomes of Chinese herbal plants such as Tenggee and Xunfengteng. It can be used to treat various rheumatic diseases such as rheumatism and rheumatoid arthritis and arrhythmia. The oral bioavailability of sinomenine hydrochloride is low, and patients need to take it orally for a long time. At the same time, it has certain side effects such as gastrointestinal irritation and rash caused by the release of histamine. At present, there are Zhengqing Fengtongning enteric-coated tablets, sustained-release tablets and injections in the domestic market. Ordinary enteric-coated sinomenine hydrochloride tablets can ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/485A61K47/38A61K47/32A61K47/10A61P19/02A61P29/00A61P9/06
CPCA61K9/4808A61K9/4816A61K31/485A61K47/10A61K47/32A61K47/38
Inventor 胡容峰朱双双陆文捷孙超杰陈轶凡
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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