Method and agent for detecting drugs in beverages

A technology of medicaments and medicines, applied in the field of medicines and reagents used to detect beverages

Inactive Publication Date: 2013-05-22
ETHYPHARM SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the system only protects those who have such a kit

Method used

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  • Method and agent for detecting drugs in beverages
  • Method and agent for detecting drugs in beverages

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Orodispersible tablets containing 5 mg zolpidem and having the following composition were prepared:

[0139] components

％

mg / unit

Zolpidem Granules

32.8

41.05

microcrystalline cellulose

10.0

12.50

Mannitol

43.7

54.57

Crospovidone

10.0

12.50

Colorant E132

0.4

0.50

aspartame

1.0

1.25

spices

0.1

0.13

silica

1.0

1.25

Magnesium stearate

1.0

1.25

total

100.0

125.0

[0140] Orodispersible tablets are prepared as follows.

[0141] Zolpidem granules are first prepared with the following percentage composition:

[0142] NPTAB 190 (180-220μm)

56

zolpidem tartrate

13

Hypromellose 603

7

1N HCl

2

Ethyl cellulose aqueous dispersion ECD30

13

Hypromellose 603

6

triethyl citrate

3

...

Embodiment 2

[0153] A conventional immediate release tablet containing 10 mg zolpidem was prepared.

[0154]

％

Mg / unit

Zolpidem Granules

32.8

82.0

microcrystalline cellulose

10.0

25.0

lactose

32.7

81.75

calcium silicate

20.0

50.0

povidone

3.0

7.5

silica

0.9

2.25

Colorant E132

0.1

0.25

Magnesium stearate

0.5

1.25

total

100.0

250.0

[0155] Pizotan granules are first prepared. Pizotan granules were prepared as in Example 1.

[0156] The pyrazolidine granules were then mixed with the excipients described in the table above. The powdered mixture is then compressed into tablets.

[0157] Then dissolve one tablet in a glass of pulpless orange juice. Immediately after adding the agent and stirring, a green color and cloudiness develop in a manner visible to the naked eye.

Embodiment 3

[0159] Two types of orodispersible tablets each containing 10 mg of pyrzotan and having the following formulations were prepared:

[0160] components

％

mg / unit

Zolpidem Granules

32.8

82.1

microcrystalline cellulose

9.6

23.90

Mannitol

30.0

75.00

Crospovidone

5.0

12.50

floating particles

20.0

50.00

Colorant E132

1.0

2.50

spices

0.1

0.25

silica

1.0

2.50

Magnesium stearate

0.5

1.25

total

100.0

250.0

[0161] These tablets were prepared as in Example 1 using the ingredients in the above table.

[0162] For the first series of tablets (C1), the levitating granules were prepared as follows:

[0163] NPTAB 190 (180-220 [mu]m) blanks were coated with an aqueous dispersion of ethylcellulose, triacetin and talc. The coating factor was 30% dry mass and the talc / polymer ratio...

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Abstract

The present invention relates to a method for combating chemical submission, which comprises: putting into solution, in a beverage, a pharmaceutical form comprising an active ingredient and at least 0.05 mg, preferably from 0.2 to 5 mg, even more preferentially from 0.3 to 2 mg of at least one water-soluble colouring agent chosen from: indigocarmine or E 132, erythrosine or E 127, brilliant blue FCF, alphazurine FG, fast green FCF, quinzarine green SS, orange II, tartrazine and Sunset yellow FCF, detecting the pharmaceutical form, said detection being characterized by the immediate change in colour of the beverage; it also relates to the use of said colorant for combating chemical submission, and also to a non-film-coated solid pharmaceutical form comprising said colorant.

Description

technical field [0001] The subject of the invention is a method for preventing the surreptitious administration of chemical drugs. Background technique [0002] For some years, offenders have been taking advantage of the hypnotic properties of certain substances to drug people without their knowledge. Criminals don't hesitate to add potions to their victims' drinks to alter their behavior or even cause them to lose their memories altogether. Once the victim loses all consciousness, criminals can profit from them: steal, rob or extort money. Moreover, the ingestion of such medicaments regardless of the prescribed dose can lead to serious consequences, especially if it is absorbed with a certain amount of alcohol. The agent can also have harmful interactions with other drugs that the victim has previously taken. [0003] From the state of the art, one sleeping pill, flunitrazepam, is known to be widely used for illicit purposes due to its readily soluble and imperceptible p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/22
CPCA61K9/2013A61K9/2081G01D7/005A61K47/20A61K9/2077A61K9/0095G01N31/22A61K9/0056A61K9/2009A61K47/22A61K9/5047A61P25/04A61P25/20A61P25/22A61P43/00
Inventor C·埃里P·孔塔曼E·迪波
Owner ETHYPHARM SA
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