Pharmaceutical composition for prevention and treatment of chronic glomerular diseases and preparation method of pharmaceutical composition

Abstract

The invention discloses a pharmaceutical composition for prevention and treatment of mesenterium proliferation acute nephritis and focal glomeruloscerosis and a preparation method of the pharmaceutical composition. The pharmaceutical composition is formed by compatibility of extractives of astragalus, panax notoginseng and salviae miltiorrhizae, and effective constituents are flavonoid, saponins and phenolic acid. Medicine materials comprise, by weight, 9-30 parts of the astragalus, 3-10 parts of the panax notoginseng, and 3-20 parts of the salviae miltiorrhizae. Salviae miltiorrhizae contents of all kinds of chemical components include that when calycosin serves as a reference substance, the total flavonoid content is 30.0-0.50%; when total saponins of the panax notoginseseng serves as a reference substance, the total saponins content is 18.0-97.0%; and when caffeic acid serves as a reference substance, the total phenolic acid content is 52.0-2.5%. The inventor of the pharmaceutical composition and the preparation method combines disease-based medicine with vidence-based medicine in long-term clinic treatment. Efficacy of the pharmaceutical composition is superior to single use of any one medicinal component or combined use of two medicinal components. The pharmaceutical composition is little in toxicity and suitable for long-term taking.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine effective component composition for preventing and treating mesangial proliferative glomerulonephritis and focal glomerulosclerosis. Specifically, it is a medicinal composition in which effective components of traditional Chinese medicines astragalus, notoginseng and salvia miltiorrhiza are compatible. Background technique

[0002] Chronic glomerulonephritis (chronic glomerulonephritis) is abbreviated as chronic nephritis. It is a group of immune diseases that originate in the glomerulus caused by various reasons, with similar clinical manifestations, different pathological changes, and different prognosis. There are different degrees of proteinuria, hematuria, edema and high blood pressure, and most of them end up with different degrees of renal function damage. The clinical onset of chronic kidney disease is insidious, the course of the disease is long, and it has a tendency of progressive deve...

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