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Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof

A technology of uterine fibroids and compositions, which is applied in the fields of traditional Chinese medicine, pharmacy and drug application, and can solve problems such as adverse reactions, poor patient acceptance, and weak drug efficacy

Active Publication Date: 2013-06-19
GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this stage, the existing product Guizhi Fuling Capsules in the market has weak efficacy and is not suitable for complicated gynecological mass diseases such as uterine fibroids, ovarian cysts, and breast hyperplasia, and it is reported that there are gastrointestinal adverse reactions. It is used for ground beetle, leech, etc., which will cause great damage to the patient's constitution. It is not suitable for long-term use, which may cause incomplete treatment, and cannot deal with gynecological mass diseases such as uterine fibroids, ovarian cysts, and breast hyperplasia. The disease is lingering and prone to repeated attacks. feature
None of the above treatment methods and drugs can satisfy the existing clinical treatment, clinicians lack choices, and patients have poor acceptance

Method used

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  • Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof
  • Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof
  • Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] (1) Composition of raw materials: 205 parts of Smilax, 126 parts of Sophora flavescens, 130 parts of Cortex Phellodendri, 128 parts of Curcuma, 135 parts of Sanleng, 215 parts of Salvia miltiorrhiza, 120 parts of Radix Paeoniae Rubra, 125 parts of Toosendan, 135 parts of Corydalis Corydalis, Cyperus cyperi 88 servings, 216 servings of angelica, 200 servings of Gorgon fruit, 250 servings of yam.

[0115] (2) Take the prescribed amount of Smilax tuckahoe, Toosendan, Corydalis, Curcuma, Sanleng, Cyperus cyperi, Radix Paeoniae Rubra, Salvia miltiorrhiza, Angelica, Sophora flavescens, Cortex Phellodendron, Gorgon fruit, Chinese yam, crush them, put them into the extraction kettle, and use carbon dioxide as the Fluid, the pressure of the extraction kettle is set to be 25Mpa, the volatile components are extracted supercritically, and the volatile components are collected, added to 1.5 times the volume of 4% cellulose acetate phthalate (CAP) solution, stirred to become a uniform...

Embodiment 2

[0119] (1) Composition of raw materials: 60 parts of Smilax, 100 parts of Sophora flavescens, 120 parts of Cortex Phellodendri, 70 parts of Curcuma, 60 parts of Sanleng, 200 parts of Salvia miltiorrhiza, 160 parts of Radix Paeoniae Rubra, 70 parts of Toosendan, 60 parts of Corydalis Corydalis, Rhizoma Cyperi 80 parts, 150 parts angelica, 80 parts Gorgon fruit, 180 parts yam.

[0120] (2) Take the prescribed amount of Smilax tuckahoe, Toosendan, Corydalis, Curcuma, Sanleng, Cyperus cyperi, Radix Paeoniae Rubra, Salvia miltiorrhiza, Angelica, Sophora flavescens, Cortex Phellodendron, Gorgon fruit, Chinese yam, crush them, put them into the extraction kettle, and use carbon dioxide as the Fluid, the pressure of the extraction kettle is set to be 21Mpa, the volatile components are extracted supercritically, and the volatile components are collected, added to 0.9 times the volume of 3.5% cellulose acetate phthalate (CAP) solution, stirred to form a uniform suspension, Keep the temp...

Embodiment 3

[0124] (1) Composition of raw materials: 100 parts of Smilax cocos, 120 parts of Sophora flavescens, 140 parts of Cortex Phellodendri, 300 parts of Curcuma, 150 parts of Sanleng, 180 parts of Salvia miltiorrhiza, 90 parts of red peony, 320 parts of Toosendan, 300 parts of Corydalis, Cyperus cyperi 160 parts, 350 parts of angelica, 40 parts of gorgon, 60 parts of yam.

[0125] (2) Take the prescribed amount of Smilax tuckahoe, Toosendan, Corydalis, Curcuma, Sanleng, Cyperus cyperi, Radix Paeoniae Rubra, Salvia miltiorrhiza, Angelica, Sophora flavescens, Cortex Phellodendron, Gorgon fruit, Chinese yam, crush them, put them into the extraction kettle, and use carbon dioxide as the Fluid, set the extraction kettle pressure to 22Mpa, supercritically extract volatile components, collect volatile components, add to 2 times the volume of 4.5% cellulose acetate phthalate (CAP) solution, stir to make a uniform suspension, Keep the temperature at 55°C, slowly add 11% acetic acid solution...

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Abstract

The invention discloses a medicine composition curing gynaecological mass diseases such as fibroids and a preparation method and application of the medicine composition. The medicine composition mainly comprises the following raw materials: glabrous greenbrier rhizome, lightyellow sophora roots, cortex phellodendri, zedoray rhizome, rhizoma sparganic, roots of red-rooted salvia, red peony roots, szechwan chinaberry fruits, rhizoma corydalis, rhizoma corydalis, chinese angelica, Gorgon fruits and Chinese yams, extraction and purification are carried out through a certain technique, and auxiliary materials and components which are acceptable in the pharmacy are added to prepare the medicine composition. According to the preparation method, volatile components are extracted in a supercritical mode and prepared into micro-capsules to avoid loss of the volatile components, the preservation time limit of the product is promoted, and the stimulus effect on gastrointestinal tracts is reduced. The method is extensive in medicinal herbs resources and free of toxic, strong and tabooed medicines, all the effective components contribute to synergistic effects, the effective substances are clear, the quality safety is controllable, the curative effect is definite, and the medicine composition can be accepted well and is a new effective medicine curing the gynaecological mass diseases such as the fibroids.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gynecological mass diseases such as uterine fibroids, and also relates to a preparation method and application of the pharmaceutical composition, belonging to the fields of traditional Chinese medicine, pharmacy and drug application. Background technique [0002] Uterine fibroids, ovarian cysts, breast hyperplasia and other gynecological mass diseases are frequently-occurring diseases in modern clinical practice. Among them, uterine fibroids are called "the first tumor in gynecology" and have been listed as intractable gynecological diseases from ancient times to the present. More common in women aged 30-50, the incidence rate of women over the age of 30 is about 20%, and the incidence rate of women aged 40-50 is the highest, which can be as high as 50-77%. Ovarian cyst is a kind of ovarian tumor and one of the common gynecological diseases. Its type ranks first in the tumors of variou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P15/00A61P35/00A61P15/08A61P15/14A61P1/16A61P13/12
Inventor 张凯谢隆谢雁鸣伍彪陈腊梅艾风
Owner GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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