Method of analyzing platelet aggregation function according to platelet size changes

A platelet aggregation and volume change technology, applied in the field of clinical laboratory medicine, can solve the problems of large error in results and cumbersome operation of electrical detection

Inactive Publication Date: 2014-09-24
SINNOWA MEDICAL SCI & TECH
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Problems solved by technology

Each of these methods has certain defects, such as the optical method and the electrical method detection operation are more loaded down with trivial details, and the result error is larger; and the counting method often has a larger difference (5-10% or higher) for counting the number of platelets, especially for low blood pressure. Value samples (platelet count less than 100×10 9 / L) When detecting

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  • Method of analyzing platelet aggregation function according to platelet size changes
  • Method of analyzing platelet aggregation function according to platelet size changes
  • Method of analyzing platelet aggregation function according to platelet size changes

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Experimental program
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Embodiment 1

[0004] Embodiment one and test data:

[0005] Mix 1 part of citrate anticoagulated blood thoroughly, test it 20 times continuously with a hematology analyzer, and record the mean platelet volume and number of platelets (before aggregation) obtained from each test at the same time; Add 0.2mmol ADP aggregation inducer to the blood sample, mix the blood sample thoroughly and put it on the instrument for detection, and record the average platelet volume value and the number of platelets (after aggregation) obtained from each test. Then get the data in Table 1. By performing calculations based on these detection data, two different platelet aggregation rate values ​​calculated by the two detection data can be obtained.

[0006] Table 1. Comparison table of repeatability of platelet aggregation rate obtained by two different detection and calculation methods

[0007]

[0008] Remark:

[0009] 1. The formula for calculating platelet aggregation rate based on the change of plate...

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Abstract

The invention discloses a method of analyzing a platelet aggregation function according to platelet size changes, and belongs to the field of clinical laboratory medicine. The method of analyzing the platelet aggregation function according to the platelet size changes measures the platelet size changes before after aggregation processing, and calculates the aggregation rate value of platelet according to the size changes of the platelet in a sample, and therefore the strength of the platelet aggregation function can be reflected. The method of analyzing the platelet aggregation function according to the platelet size changes also can be applied to erythrocyte aggregation rate analysis.

Description

1. Technical field [0001] The invention relates to a detection and analysis method for evaluating platelet aggregation rate of tested blood samples by measuring the volume change of platelets before and after aggregation, and belongs to the field of clinical laboratory medicine. 2. Background technology [0002] Platelet aggregation function (generally expressed as aggregation rate) is an important function of platelets in blood, which is related to blood coagulation function. The existing detection method is mainly to detect the change of optical density (or luminous flux performance) in plasma after platelet aggregation in plasma or whole blood (abbreviation: optical method), or put the electrode into the whole blood to be tested to observe the blood sample and add aggregation induction. Electrode resistance change (abbreviation: electrical method) caused by the adsorption of platelets on the electrode after injection, or direct counting of changes in the number of platele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/49
Inventor 徐新董自权曹宁周强
Owner SINNOWA MEDICAL SCI & TECH
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