Fructus aurantii immaturus or fructus aurantii total-flavonoid extract obtained through ethanol reflux extraction and application thereof

Abstract

The invention relates to a fructus aurantii immaturus or fructus aurantii total-flavonoid extract. The fructus aurantii immaturus or fructus aurantii total-flavonoid extract is obtained through the steps of: cutting fructus aurantii immaturus or fructus aurantii into decoction pieces or crushing the fructus aurantii immaturus or fructus aurantii, adding 30-90% ethanol of a volume which is 5-16 times that of the fructus aurantii immaturus or fructus aurantii, carrying out reflux extraction for 1-3 times, and filtrating, wherein the time for reflux extraction per time is 1-3 hours; and combining filtrates, recovering ethanol from the filtrates, enabling a water solution to pass through processed non-polar macroporous resin, eluting by sequentially using water and ethanol with the concentration below 20% so as to remove impurities, eluting by using 25-90% ethanol and 0.5-2% sodium hydroxide, collecting ethanol eluent, carrying out reduced pressure concentration on the ethanol eluent at the temperature of 50-70 DEG C until the relative density of a fluid extract is 1.20-1.40, carrying out drying under reduced pressure, and crushing, thereby obtaining the fructus aurantii immaturus or fructus aurantii total-flavonoid extract, wherein the drying temperature is 60-80 DEG C. The extract can be used for preparing drugs for gastrointestinal dyskinetic functional dyspepsia, epigastric pain, abdominal distention, anorexia, eructation, nausea, vomit and chemotherapy and drugs for vomit caused by other causes.

Description

technical field [0001] The invention relates to a total flavonoid extract of Fructus aurantium or Fructus aurantii extracted by ethanol reflux and use thereof. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. Also known as gastric insufficiency, or gastric motility disorder. Is a common clinical syndrome, foreign statistics show that 1 / 3 of the population suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of digestive system outpatients, and occurs in 20% to 40% of normal people. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are Metoclon and Zofran, but chemical drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscle pain. Cramp symptoms. [0003] At present, Western medicine mainly treats modinline, cisapride, mosapride, etc.; however, with the extensive use of them, it i...

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

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