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Traditional Chinese medicine composition used for treating septicopyemia and preparation method of traditional Chinese medicine composition

A technology of sepsis and composition, which is applied in the field of traditional Chinese medicine composition for treating sepsis and its preparation, which can solve problems such as failure to obtain particularly satisfactory curative effect and unsatisfactory therapeutic effect, and achieve reduction or inhibition of systemic inflammation response, reduce patient mortality, and improve efficiency

Inactive Publication Date: 2014-07-02
曹丙玉
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] The fundamental pathogenesis of sepsis has not been fully elucidated by modern medicine, and the clinical treatment has not achieved particularly satisfactory curative effect, and the main treatment is symptomatic and supportive. Although based on the research of modern molecular biology, the developed Some drugs can be targeted at some pathogenesis or mechanism. However, due to the complexity and diversity of the pathogenesis of sepsis, treatment aimed at one pathogenesis or pathogenesis alone often cannot achieve satisfactory therapeutic effects.

Method used

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  • Traditional Chinese medicine composition used for treating septicopyemia and preparation method of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 The specific preparation of injection 1

[0075] Cinnamomum twig 25g, dandelion 50g, saponin thorn 20g, magnolia bark 15g, amomum 15g, radix radix 35g, gardenia 45g, forsythia 75g, nepeta 15g, astragalus 60g, atractylodes macrocephala 45g, heterophylla 35g, red peony root 25g , Shichangpu 20g, Apocynum leaves 25g, kudzu root 15g, leeches 30g, notoginseng 35g, cortex 50g, dog ridge 25g, angelica 30g, medlar 40g, ferulicum 20g, catechu 15g, mother clove 25g, turmeric 35g, 30g of Daxueteng, 35g of Asparagus and 20g of Scutellaria chinensis were crushed separately, mixed to obtain a mixture, added water to submerge 5cm of the medicine surface of the mixture, soaked for 2 hours, heated and decocted, boiled with a slow fire, and decocted after the first boiling for 4 After 1 hour, filter out the liquid medicine, add water to the filter residue again until the surface of the mixture is submerged by 5cm, heat to boil, then use a slow fire after boiling, decoct for ...

Embodiment 2

[0076] Embodiment 2 Toxicology experiment

[0077] Choose 60 KM mice, divide into treatment group and matched group at random according to body weight, every group is 30, male and female half and half, before administration fasting can't help water 12 hours, the present invention treats group mice according to the administration of 0.25ml / 10g The drug volume was administered intravenously; the control group was given intragastric water. Immediately after administration, observe the reaction of the animal, including the animal's shape, behavior, mental state, appetite, urine and stool and its color, whether there are abnormal secretions in the fur, nose, eyes, and mouth, and the death of the animal. Dead animals should be autopsyed in time , Histopathological examination was performed if there were visible lesions. On the first day of administration, observations were made every 1 hour, and thereafter, observations were made every day for 7 consecutive days, and animal toxicit...

Embodiment 3

[0078] Embodiment 3 The specific preparation of injection 2

[0079] Cinnamon twig 23g, dandelion 48g, saponin thorn 18g, magnolia bark 13g, amomum 13g, radix radix 33g, gardenia 43g, forsythia 73g, nepeta 13g, astragalus 58g, atractylodes macrocephala 43g, heterophylla 33g, red peony root 23g , Shichangpu 18g, Apocynum leaves 23g, kudzu root 13g, leech 28g, notoginseng 33g, cortex 48g, dog ridge 23g, angelica 28g, medlar 38g, asafoetida 18g, catechu 13g, mother clove 23g, turmeric 33g, 28g of Daxueteng, 33g of Asparagus and 18g of Scutellaria chinensis were respectively crushed and mixed to obtain a mixture. Add water until the surface of the mixture was submerged by 4cm, soak for 2 hours, heat and decoct, boil with a slow fire, and decoct for 3 After 1 hour, filter out the liquid medicine, add water to the filter residue again until the surface of the mixture is submerged by 4cm, heat to boil, then use a slow fire after boiling, decoct for 2 hours after boiling for the secon...

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Abstract

The invention provides a traditional Chinese medicine composition used for treating septicopyemia. Medicinal raw materials of the traditional Chinese medicine composition include cassia twig, dandelion, spina gleditsiae, mangnolia officinalis, fructus amomi, radix ophiopogonis, fructus gardeniae, fructus forsythiae, schizonepeta, astragalus mongholicus, bighead atractylodes rhizome, radix pseudostellariae, radix paeoniae rubra, acorus gramineus, folium apocyni veneti, kudzuvine root, leech, panax notoginseng, amur corktree bark, rhizoma cibotii, angelica sinensis, barbary wolfberry fruit, ferula asafoetida, acacia catechu, fructus caryophylli, radix curcumae, sargentgloryvine stem, asparagus and glabrous sarcandra herb. When the traditional Chinese medicine composition is used together with conventional western medicine treatment, release of inflammatory medium and endotoxin can be effectively resisted, patient symptoms can be improved, systemic inflammatory response can be relieved or inhibited, system functions of each organ can be protected, the efficiency of treatment on septicopyemia can be improved, and the patient death rate can be reduced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating sepsis and a preparation method thereof. Background technique [0002] Sepsis is a huge threat to the current ICU, and the resulting shock and multisystem organ failure (MODS) have become one of the most important causes of death in the ICU, seriously threatening the lives of patients, with a high mortality rate. Sepsis is a common and complex problem faced by modern critical care medicine, and it has become a prominent problem that directly affects the prognosis of patients and hinders the further improvement of the success rate of treatment. In recent years, research on the pathogenesis and clinical significance of sepsis has made some progress, but there is still no effective specific treatment in clinical practice, and the mortality rate is still 28%-50%. Facing the grim situation, more and more sch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/08A61P31/00A61P29/00A61K35/62A61K127/00
Inventor 曹丙玉刘淑彬周新卫于芳陈芳
Owner 曹丙玉
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