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Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof

A technology for gastric mucosa protection and sea buckthorn seed oil, which is applied in the field of medicine, can solve the problems of difficult long-term and daily use, poor adaptability of injection patients, etc., and achieves the effects of improving bioavailability, no toxic and side effects, and significant protection and repairing effects.

Inactive Publication Date: 2013-07-24
史小军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients with injections have poor adaptability and are not easy to use for a long time and daily

Method used

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  • Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof
  • Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof
  • Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Stir 1.5g of phospholipid, 0.1g of vitamin E, 0.1g of sodium oleate and 10g of seabuckthorn oil at 50-60°C and disperse evenly as the oil phase; mix 5g of glycerin and 80mL of purified water at 50-60°C as the water phase , Pour the oil phase into the water phase and stir for 10 hours, use high shear to help emulsify, repeat 2-4 times to obtain colostrum, add this colostrum to the purified water preheated to 50-60°C to the full amount, transfer to high-pressure homogenization Homogenize 6 times under 80MPa pressure in the quality machine, fill with N after filtering 2 Potting, sterilizing in a rotating water bath at 119°C-123°C to obtain the product, and refrigerating at 6-20°C in the dark.

Embodiment 2

[0081] Stir 1.5g of phospholipid, 0.1g of vitamin E, 0.2g of poloxamer F68 and 10g of seabuckthorn oil at 50-60°C and disperse evenly as the oil phase; mix 2.5g of glycerin and 80mL of purified water at 50-60°C As the water phase, pour the oil phase into the water phase and stir for 10 hours, use high shear to help emulsify, repeat 2-4 times to obtain colostrum, add the colostrum to the purified water preheated to 50-60°C to the full amount, turn to Homogenize 6 times under 80MPa pressure in a high-pressure homogenizer, fill with N after filtering 2 Potting, sterilizing in a rotating water bath at 119°C-123°C to obtain the product, and refrigerating at 6-20°C in the dark.

Embodiment 3

[0083] Stir 2g of phospholipids, 0.1g of vitamin E, 0.2g of poloxamer F68 and 10g of seabuckthorn oil at 50-60°C and disperse evenly as the oil phase; 2.5g of glycerin, 0.1g of disodium edetate and 80mL of purified water Mix at 50-60°C as the water phase, pour the oil phase into the water phase and stir for 10 hours, use high shear to help emulsify, repeat 2-4 times to obtain colostrum, add this colostrum to preheat to 50-60°C Purified water to the full amount, transferred to a high-pressure homogenizer for homogenization under 80MPa pressure for 6 times, filtered and filled with N 2 Potting, sterilizing in a rotating water bath at 119°C-123°C to obtain the product, and refrigerating at 6-20°C in the dark.

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a seabuckthorn seed oil oral emulsion. The seabuckthorn seed oil oral emulsion is characterized by being prepared from the following components in percentage by weight: 1-20% of seabuckthorn seed oil, 0.5-30% of emulsifier, 0.1-20% of assistant emulsifier, 0.001-5% of antioxidant, 0-0.5% of corrigent and the balance of purified water. The preparation method is emulsification. Compared with the existing products, the seabuckthorn seed oil oral emulsion has the advantages that dispersibility of drops in emulsion droplet is good, and the superficial area is large and is favorable to the absorption of the seabuckthorn seed oil and exerting of the efficacy, so that the bioavailability is improved and bad odor and taste of oil can be covered. The emulsion prepared is suitable for oral administration. The pharmacodynamic experiment shows that the oral emulsion has better effect as compared with crude oil, and the use dose of the crude oil can be greatly reduced. Compared with chemical medicines, the emulsion provided by the invention is free from toxic and side effect, remarkable in curative effect and wide in adaptation disease, and has great social and economic values.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an oral emulsion which has the function of repairing gastric mucosal damage and can be used as a partner of chemotherapy drugs, its preparation method and application. Background technique [0002] More than 40 million people around the world suffer from cancer, and every 6 seconds on average, cancer ruthlessly kills a life, which is creepy. At present, there are three methods in the medical field to deal with cancer: surgical resection of cancer, chemotherapy, and radiotherapy. But these three methods are all aggressive therapies, which will cause huge harm to the patient's body. Therefore, when the causes of cancer and targeted treatment drugs have not yet been resolved, scientists advocate: under the condition that effective cancer drugs and methods have not yet been found, it is crucial to prevent cancer and improve the quality of life of cancer patients . [0003] Known as...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K36/185A61P1/04A61P35/00
Inventor 史小军于辉天刘丹
Owner 史小军
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