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Biological medical degradable material and preparation method thereof

A degradable material, biomedical technology, applied in electrolytic coating, anodic oxidation, coating, etc.

Inactive Publication Date: 2015-03-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a biomedical degradable new material and its preparation method in view of the outstanding problems existing in the existing biomedical materials and their application technologies

Method used

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  • Biological medical degradable material and preparation method thereof
  • Biological medical degradable material and preparation method thereof
  • Biological medical degradable material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The sample of high-purity magnesium as cast metal was taken as the research object. Using distilled water as solvent, prepare 20.0g / L sodium chloride solution as anodic polarization electrolyte. Connect the equal-area samples of the same material to the wires, then connect them to the two output ports of the sinusoidal AC power supply, and immerse them in the above-mentioned electrolyte with a temperature control of 25°C, keep the distance between the samples at 3cm, and use a constant current of 1.0mA / cm at 50Hz 2 After processing for 30 minutes, it was found that the surface of the sample was evenly distributed with finely crushed pits with the same size and depth visible to the naked eye. The washed and dried anodized sample and the stainless steel cylinder form an electrode pair, the sample is connected to the negative pole of the DC power supply, and the stainless steel cylinder is connected to the positive pole of the DC power supply, respectively immersed in 50.0...

Embodiment 2

[0059] The sample of AZ31 magnesium alloy in mold casting state was taken as the research object. Except that the concentration of sodium chloride was changed to 100.0g / L, the other conditions of anodic polarization were controlled the same as in Example 1. It was found that, except that the area of ​​a single pit increased, the density of pits and their distribution uniformity decreased, the others were the same as in the implementation example 1. Except that the concentration of magnesium chloride was changed to 0.5g / L, other conditions and results of cathodic deposition were the same as in Example 1. Using chloroform as a solvent, first prepare four parts of 30.0g / LPLLA solution, then add 10.0g / L magnesium hydroxide and pure magnesium powder (spherical, median particle size d 50 =47 μm), β-TCP and CPP, stirred evenly to obtain suspensions, which were marked as solution S 04 , S 05 , S 06 and S 07 . Carry out two rounds of dip-coating treatment on the cathodic depositi...

Embodiment 3

[0061] The sample of AZ91 magnesium alloy in mold casting state was taken as the research object. Except that the concentration of sodium chloride was changed to 20m.0g / L, other conditions of anodic polarization were controlled as in Example 1. It was found that the treatment effect was the same as in Example 1 except that the density and depth of pits were reduced. Except that the concentration of magnesium chloride was changed to 150.0g / L, other conditions and results of cathodic deposition were the same as in Example 1. Using chloroform as solvent, prepare 75.0g / LPLLA solution, marked as solution S 08 ; Take ethanol as dispersant (liquid), add 0.5g / L magnesium hydroxide (solid dispersed phase), stir well to obtain a suspension, marked as solution S 09 . Using dichloromethane as a solvent, first prepare a 75.0g / L PLLA solution, then add 0.377g / L magnesium oxide and stir well to obtain a suspension, which is marked as solution S 10 . The cathodic deposition sample after w...

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Abstract

The invention discloses a biological medical degradable material and a preparation method thereof. The preparation method of the material mainly comprises the following steps: 1) smelting and forming; 2) anodic polarization; 3) cathodic deposition; and 4) coating. The material disclosed by the invention comprises a pure magnesium or magnesium alloy base and a functional film covered on the base surface with degradation protection and self-degradation characteristics; and the integral material has the characteristic of controllable all-degradable absorption, and satisfies the serious requirements for ideal characteristics of degradable biological materials. The invention provides a preferred scheme for solving the contradiction between biodegradable characteristic utilization and degradation rate control of the absorbable biological material, especially medical magnesium alloy; and the related material and technique are not only suitable for common medical appliance products, but also have competitive edges in manufacturing of high-end medical appliance products, such as implantation instruments, especially secondary-operation-free implantation substances.

Description

technical field [0001] The invention belongs to the technical field of manufacturing and application of biomedical new materials and medical device products, and in particular relates to a biomedical degradable new material and a preparation method thereof. Background technique [0002] With the development of social economy and the improvement of living standards, human beings are paying unprecedented attention to their own medical and health undertakings. The increasing pressure of survival, the accelerated pace of life, the intensification of environmental pollution, the frequent occurrence of food, transportation and production safety accidents, local wars, and natural disasters have caused diseases and traumas to become the ever-lingering haze of human beings. As an important means of modern medicine—an important basis and component of medical devices, biomaterials are used for the diagnosis and treatment of diseases, the repair, replacement or function enhancement of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L27/34A61L27/32A61L27/28C25D11/30C25D9/12
Inventor 张永君贾书功夏兰梅沈军董连军李爱红陶胜
Owner SOUTH CHINA UNIV OF TECH
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