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Nifedipine slow release tablet and preparation method thereof

A nifedipine, gentle technology, applied in the field of medicine, can solve the problems of increasing the content of related substances in preparations, and achieve the effects of complete drug release, improved solubility, and good controlled release

Active Publication Date: 2013-09-18
ZHEJIANG ANGLIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the sustained-release preparation prepared by this technology can release nifedipine slowly and continuously, it is necessary to hot-melt extrude nifedipine, hydroxypropyl cellulose and microcrystalline cellulose through a twin-screw extruder during the preparation process, which is easy to increase Content of related substances in the preparation

Method used

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  • Nifedipine slow release tablet and preparation method thereof
  • Nifedipine slow release tablet and preparation method thereof
  • Nifedipine slow release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]

[0030] Preparation Process:

[0031] Weigh the prescribed amount of nifedipine and povidone, add it to ethanol, stir to dissolve, evaporate the solution under reduced pressure to a paste, then add it to the molten glyceryl behenate at 70°C, stir evenly, cool, and pulverize , passed through a 100-mesh sieve, then mixed evenly with the prescribed amount of lactose and magnesium stearate, and compressed into tablets.

Embodiment 2

[0033]

[0034]

[0035] Preparation Process:

[0036] Weigh the prescribed amount of nifedipine and povidone, add it to ethanol, stir to dissolve, evaporate the solution under reduced pressure to a paste, then add it to the molten glyceryl behenate at 75°C, stir evenly, cool, and pulverize , passed through a 100-mesh sieve, and finally mixed evenly with the prescribed amount of microcrystalline cellulose, mannitol, magnesium stearate, and micropowder silica gel, and pressed into tablets.

Embodiment 3

[0038]

[0039] Preparation Process:

[0040]Weigh the prescribed amount of nifedipine and povidone, add it to ethanol, stir to dissolve, evaporate the solution under reduced pressure to a paste, then add it to the molten glyceryl behenate at 80°C, stir evenly, cool, and pulverize , passed through a 100-mesh sieve, finally mixed evenly with the prescribed amount of microcrystalline cellulose and magnesium stearate, and compressed into tablets.

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Abstract

The invention discloses a nifedipine slow release tablet. The nifedipine slow release tablet is formed through uniformly mixing and tabletting medicine-carrying particles and pharmaceutically acceptable auxiliary materials. The method for preparing the medicine-carrying particles comprises the following steps of: dissolving nifedipine and povidone in ethanol, evaporating an obtained mixed solution till the mixed solution becomes viscous, adding the viscous mixed solution into into docosanoic acid glyceride meltwater, fully stirring, cooling, smashing and sieving. The nifedipine slow release tablet provided by the invention improves the solubility of the nifedipine, well controls the release of the nifedipine, the process is simple, and the nifedipine slow release tablet is suitable for requirements of large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a nifedipine slow-release tablet and a preparation method thereof. Background technique [0002] Nifedipine is a dihydropyridine calcium ion channel antagonist, which is suitable for various types of hypertension and has a good effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term use. Nifedipine has the strongest effect on expanding coronary arteries and peripheral arteries, and has a significant effect on inhibiting vasospasm. It is the drug of choice for variant angina. It is clinically applicable to the prevention and treatment of angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. In addition, it is also suitable for patients with angina pectoris suf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4422A61K47/32A61P9/12A61P9/04A61P9/10
Inventor 徐成苗方南平杨国栋严立勇周军马海岭
Owner ZHEJIANG ANGLIKANG PHARMA
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