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Natural pharmaceutical composition

A technology of natural medicines and compositions, applied in the direction of drug combinations, antineoplastic drugs, pharmaceutical formulas, etc., can solve the problems of patients with dehydration, acid-base balance imbalance, malnutrition, etc., and achieve increased inhibition, enhanced inhibition, and good side effects Effect

Inactive Publication Date: 2013-09-25
石强
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Natural pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0036] The first step: preparation of various extracts

[0037] (1) Preparation of the concentrated extract of radish seed and longum longum decocted in water

[0038] According to the compatibility ratio of 1-6:1, take radish and longum, soak in distilled water, heat and decoct for 1 hour, filter with silk cloth, add distilled water to the medicine dregs, soak, decoct and filter in the same way, mix the two filtrates, and heat Concentrate, filter with an ultrafiltration membrane, and dry under reduced pressure to obtain the obtained product.

[0039] (2) Preparation of Raphanusin

[0040] Grind radish seeds, add excess n-hexane to degrease, enzymatically hydrolyze with pH 7.0 phosphate buffer, add dichloromethane to extract 3 times, combine solvents, remove organic solvent under reduced pressure, and dissolve the residue with 10% ethanol solution by volume fraction , extracted three times with n-hexane to remove grease, then extracted the ethanol phase three times with dich...

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Abstract

The invention relates to a natural pharmaceutical composition. The natural pharmaceutical composition is prepared from radish seed and long pepper water decoction and concentration extract, raphanin, ethanol extract of long pepper and piperine in a ratio of (3-6):(3-8):(2-5):(4-6). The composition has great curative effects on cancer chemotherapy-induced diarrhea and meanwhile has a synergistic effect on cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of natural medicine composition, more specifically relate to a kind of natural medicine composition that is composed of the concentrated extract of water decoction of radish seed and longum longum, radishin, ethanol extract of Piper longum and piperine, the natural medicine composition The preparation method of the medicine and the application of the natural medicine composition in the preparation of medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs are cytotoxic anti-tumor drugs, whether they are used alone or in combination, they will cause t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61P1/12A61P35/00A61K31/4525A61K31/26
Inventor 石强
Owner 石强
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