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Method and device for drug loading in solid microneedle array device

A technology of microneedle arrays and devices, applied in the directions of microneedles, needles, and drug devices, can solve problems such as drug inactivation, uneven drug loading, and drug waste.

Active Publication Date: 2015-11-04
BEIJING CAS MICRONEEDLE TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One of the purposes of the present invention is to overcome the limitations of the existing methods of loading drugs on solid microneedle array devices (such as: need for precise control, easy to inactivate drugs, uneven drug loading, resulting in waste of drugs, etc.), to provide a Method for drug loading of solid microneedle array device

Method used

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  • Method and device for drug loading in solid microneedle array device
  • Method and device for drug loading in solid microneedle array device
  • Method and device for drug loading in solid microneedle array device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Please refer to Figure 1 (the drug loading of the solid microneedle array device is performed manually), the device for manually loading the solid microneedle array device includes a grooved bottom plate 1 made of ordinary glass and a frame made of 304 stainless steel Type scraper 3; the frame scraper 3 is installed on the groove bottom plate 1, and the frame scraper 3 and the groove 2 of the groove bottom plate 1 together form a liquid storage pool4. Groove 2 has a depth of 75 μm, a width of 10 mm, and a length of 30 mm. The frame scraper 3 is a square frame with a side length of 10 mm and a height of 10 mm.

[0052] The material of the microneedles on the used solid microneedle array device 6 is monocrystalline silicon material, the array is 6×6, and the array area is 0.25cm 2 , consisting of 36 microneedles, the length of each microneedle is 100 μm, the diameter of the tip is 100 nm, and the maximum cone angle of the tip is 20°. The back of the solid microneedle a...

Embodiment 2

[0056] Please refer to Figure 1 (the drug loading of the solid microneedle array device is performed manually), the device for manually loading the solid microneedle array device includes a grooved bottom plate 1 made of an aluminum plate and a frame-type scraper made of polytetrafluoroethylene. Plate 3; the frame-type scraper 3 is installed on the groove bottom plate 1, and the frame-type scraper 3 and the groove 2 of the groove bottom plate 1 together form a liquid storage pool 4 . Groove 2 has a depth of 300 μm, a width of 14 mm, and a length of 30 mm. The frame scraper 3 is a square frame with a side length of 14 mm and a height of 10 mm.

[0057] The material of the microneedles on the used solid microneedle array device 6 is polymer polylactic acid material, the array is 9×9, and the array area is 0.64cm 2 , consisting of 81 microneedles, the length of each microneedle is 500 μm, the diameter of the tip is 200 nm, and the maximum cone angle of the tip is 26°. The back...

Embodiment 3

[0061] Please refer to Figure 1 (the drug loading of the solid microneedle array device is performed manually), the device for manually loading the solid microneedle array device includes a groove bottom plate 1 made of stainless steel plate and a frame made of 304 stainless steel Type scraper 3; the frame scraper 3 is installed on the groove bottom plate 1, and the frame scraper 3 and the groove 2 of the groove bottom plate 1 together form a liquid storage pool4. Groove 2 has a depth of 500 μm, a width of 14 mm, and a length of 30 mm. The surface of the groove is treated with hydrophilicity (according to the volume unit of HCl aqueous solution. 2 H with a volume mass concentration of 30% 2 o 2 composed of hydrophilizing reagents for one minute). The frame scraper 3 is a square frame with a side length of 14 mm and a height of 10 mm.

[0062] The material of the microneedles on the used solid microneedle array device 6 is stainless steel, the array is 9×9, and the array a...

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Abstract

The invention relates to a method and a device for carrying medicines through a solid micro-needle array device. The capillary phenomenon is weakened by utilizing an adhesive force of a medicine solution and a groove base plate, and a thin liquid layer of micrometer scale, so that the accurate, uniform and economic medicine carrying through a needle point of a micro needle on the solid micro-needle array device is realized. The method for carrying the medicines through the solid micro-needle array device is as follows: the needle point of the micro needle on the solid micro-needle array device is arranged in the thin liquid layer of the medicine solution of which the thickness is micrometer scale according to the own gravity of the solid micro-needle array device, so that the medicine solution is adsorbed on the needle point of the micro needle, thereforeby the medicine carrying of the solid micro-needle array device is realized. The device provided by the invention is a manual and automatic device for carrying the medicines through the solid micro-needle array device, which is designed according to a principle of the method for carrying the medicines through the solid micro-needle array device; and the automation of the formation of the thin liquid layer, and the arrangement and switching of the solid micro-needle array device can be realized, so that the errors brought by manual operation areis avoided, and the medicine carrying process is uniform.

Description

technical field [0001] The invention relates to a drug-loading method for a solid microneedle array device and a drug-loading device for a solid microneedle array device. Specifically, it uses the adhesion force between the drug solution and the bottom plate of the groove and the micron-scale thin liquid layer to weaken the capillary phenomenon, Therefore, accurate, uniform and economical drug loading of the needle tip of the microneedle on the solid microneedle array device is realized. Background technique [0002] The way of transdermal drug delivery is hindered by the stratum corneum, so the drugs that can be used for transdermal drug delivery are greatly limited. In order to overcome the hindering effect of the stratum corneum, there are many methods at present, which can be divided into two categories: active methods and passive methods. Among various active methods, the solid microneedle array device has the advantages of simple use and no need for external energy, s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 高云华陈健敏
Owner BEIJING CAS MICRONEEDLE TECH LTD