Aromatic ruthenium complex and synthetic method thereof

A kind of technology of ruthenium complex and synthesis method, applied in the field of aromatic ruthenium complex and synthesis thereof

Inactive Publication Date: 2013-11-27
WENZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Based on the principle of hydrophilic-hydrophobic balance of drugs, combined with the advantages and disadvantages of 5-fluorouracil and arene ruthenium complexes, 5-fluorouracil was spliced ​​into diamine arene ruthenium complexes, and Schiff base C=N double bonds and nitric acid were introduced at the same time. Based on the preparation of aromatic hydrocarbon ruthenium complexes with both pH-regulated release and photosensitive activation, the development of aromatic hydrocarbon ruthenium complexes as targeted transport tools for tumor treatment has not been reported so far.

Method used

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  • Aromatic ruthenium complex and synthetic method thereof
  • Aromatic ruthenium complex and synthetic method thereof
  • Aromatic ruthenium complex and synthetic method thereof

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Embodiment Construction

[0027] A kind of aromatic hydrocarbon ruthenium complex, has the structure shown in general formula (I), (II), (III), (IV):

[0028]

[0029] ( I ) ( II )

[0030]

[0031] ( III ) ( IV )

[0032] Aromatic hydrocarbons in all the above formulas for or or or , the leaving group X is Cl or Br or I;

[0033] The above general formula (I) is an aromatic hydrocarbon ruthenium complex with anticancer activity, wherein the chelating diamine ligand is 1,2-ethylenediamine, 1,2-cyclohexanediamine or o-phenylenediamine or 4-nitro-o-phenylenediamine;

[0034] The above general formula (II) is an aromatic hydrocarbon ruthenium complex with a pH-regulated release function. When the ligand is conjugated to an aromatic ring and a nitro group is introduced on the aromatic ring, photosensitive activation can be achieved, in which the Schiff base chelates the diamine ligand for or or or ;

[0035] Above-mentioned general formula (III) is the a...

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Abstract

The invention relates to an aromatic ruthenium complex and a synthetic method thereof. According to the technical scheme, the aromatic ruthenium complex has a structure as shown in formulas (I), (II), (III) and (IV). The method comprises the following steps of: a, placing an aromatic dichloride ruthenium dimer and a chelating diamine ligand into a methanol solution to obtain the aromatic ruthenium complex; b, placing the aromatic dichloride ruthenium dimer and a schiff bases chelating diamine ligand into the methanol solution to obtain the aromatic ruthenium complex; c, placing aromatic dichloride ruthenium dimer and 5-fluorouracil containing schiff bases chelating diamine ligand into the methanol solution to obtain the aromatic ruthenium complex; and d, reacting an aldehyde group containing anti-cancer drug or an anti-cancer drug with the aldehyde group introduced by drug modification with a chelating diamine compound to obtain the schiff bases chelating diamine ligand; and then hitching into the aromatic ruthenium complex. According to the scheme, a 5-fluorouracil aromatic ruthenium complex with anticancer synergistic effect can be prepared.

Description

technical field [0001] The invention relates to an aromatic hydrocarbon ruthenium complex and a synthesis method thereof. Background technique [0002] Cancer seriously threatens human life and health. Statistics show that the number of people who die from various types of cancer accounts for about 25% of all deaths in the UK every year, and about 70% of cancer patients come from people over the age of 60. About one-third of people in the whole society will suffer from various cancers in their lifetime, and one-quarter of people will die from various diseases caused by cancer. [0003] Many factors may induce cancer, such as: gene variation and inheritance, bacterial infection and chemical carcinogens, high-energy rays and electromagnetic radiation, etc. At present, the treatment of cancer mainly relies on surgical resection, chemotherapy, radiation therapy, photodynamic therapy and so on. Among them, chemotherapy is an effective treatment method to kill cancer cells with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
Inventor 胡茂林李贤川
Owner WENZHOU UNIVERSITY
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