Systems and methods for generating control parameters for cardiac resynchronization therapy using ventricular activation simulation and surface ecg recordings

A technology for cardiac resynchronization and parameter control, which can be used in therapy, electrotherapy, medical simulation, etc., and can solve problems such as ventricular conduction delay volume remodeling and unresponsiveness

Inactive Publication Date: 2016-08-10
THE BRIGHAM & WOMEN S HOSPITAL INC
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Problems solved by technology

This suggests that despite conventional CRT pacing, uncorrected ventricular conduction delay is still largely responsible for unresponsive volume remodeling
[0007] A limitation of existing CIED methods for automatic or semi-automatic adjustment of the pacing control system for CRTs is that they rely only on limited device-based measurements that have not been correlated to any clinical outcome measures (particularly inverse volumetric remodeling). Improve

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  • Systems and methods for generating control parameters for cardiac resynchronization therapy using ventricular activation simulation and surface ecg recordings
  • Systems and methods for generating control parameters for cardiac resynchronization therapy using ventricular activation simulation and surface ecg recordings
  • Systems and methods for generating control parameters for cardiac resynchronization therapy using ventricular activation simulation and surface ecg recordings

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[0031] Conventional cardiac pacing with implanted cardiac rhythm management (“CRM”) devices, such as pacemakers and implantable cardioverter-defibrillators (“ICDs”) Intracardiac electrodes in partial electrical contact deliver electrical pacing pulses to the patient's heart. The CRM device is typically implanted subcutaneously in the patient's chest.

[0032] see now figure 1 , shows an exemplary cardiac implantable electrical device ("CIED") 100 used for cardiac resynchronization therapy ("CRT"). Such an exemplary CIED 100 includes an implantable pulse generator 102 in electrical communication with an intracardiac lead system 104 .

[0033] Portions of intracardiac lead system 104 may be inserted into patient's heart 106 through a vessel of the upper venous system, such as the superior vena cava. The intracardiac lead system 104 includes one or more electrodes configured to generate pulses representing pulses at the electrode locations, between spatially spaced electrodes,...

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Abstract

A system and method for cardiac resynchronization therapy ("CRT") using a model of baseline cardiac electrical activity, such as a model of global baseline cardiac electrical activity derived from various surface electrocardiogram ("ECG") signals, to automatically adjust pacing control parameters of a cardiac implantable electrical device ("CIED"). The baseline model is iteratively modified with simulated pacing control parameters until ventricular electrical asynchrony is minimized. An updated model of ventricular activity was generated using simulated pacing control parameters resulting in minimal ventricular electrical asynchrony, and this updated model was used to generate control parameters for CIED using the QRS grapheme morphology framework.

Description

[0001] Cross References to Related Applications [0002] This application claims the title "Integration of Ventricular Activation Simulations and Surface ECG Registration with System and Methods for Automatically Generating Ventricular Activation Wavefront Fusion During Multisite Pacing Therapy" filed on February 1, 2011 and body surface ECG recordings with a system and method for automatically generating ventricular activity wave fusion)" of U.S. Provisional Patent Application Serial No. 61 / 462,366. Background of the invention [0003] The field of the invention is systems and methods for cardiac rhythm management. More specifically, the present invention relates to systems and methods for performing cardiac resynchronization therapy, in which cardiac electrical activity models, such as simulated and derived global cardiac electrical activity models, are automatically made For the adjustment of pacing control parameters. [0004] LV conduction delay due to bundle branch blo...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/362A61N1/365A61B5/0402A61B5/0452A61N1/05G16H20/30G16H40/60
CPCA61B5/4836A61N1/3627A61N1/36585G16H50/50G16H40/60G16H20/30A61B5/327A61B5/349A61N1/36592
Inventor M·O·斯维尼
Owner THE BRIGHAM & WOMEN S HOSPITAL INC
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