System and method for cardiac resychronization therapy control parameter generation using ventricular activation simulation and surface ECG registration

A technology for cardiac resynchronization and parameter control, which can be used in computer-aided therapy prescription/delivery, therapy, electrotherapy, etc.

Inactive Publication Date: 2013-11-27
THE BRIGHAM & WOMEN S HOSPITAL INC
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Problems solved by technology

This suggests that despite conventional CRT pacing, uncorrected ventricular conduction delay is still largely responsible for unresponsive volume remodeling
[0007] A limitation of existing CIED methods for automatic or semi-automatic adjustment of the pacing control system for CRTs is that they rely only on limited device-based measurements that have not been correlated to any clinical outcome measures (particularly inverse volumetric remodeling). Improve

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  • System and method for cardiac resychronization therapy control parameter generation using ventricular activation simulation and surface ECG registration
  • System and method for cardiac resychronization therapy control parameter generation using ventricular activation simulation and surface ECG registration
  • System and method for cardiac resychronization therapy control parameter generation using ventricular activation simulation and surface ECG registration

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[0031] Conventional cardiac pacing with implanted cardiac rhythm management (“CRM”) devices, such as pacemakers and implantable cardioverter-defibrillators (“ICDs”) Intracardiac electrodes in partial electrical contact deliver electrical pacing pulses to the patient's heart. The CRM device is typically implanted subcutaneously in the patient's chest.

[0032] see now figure 1 , shows an exemplary cardiac implantable electrical device ("CIED") 100 used for cardiac resynchronization therapy ("CRT"). Such an exemplary CIED 100 includes an implantable pulse generator 102 in electrical communication with an intracardiac lead system 104 .

[0033] Portions of intracardiac lead system 104 may be inserted into patient's heart 106 through a vessel of the upper venous system, such as the superior vena cava. The intracardiac lead system 104 includes one or more electrodes configured to generate pulses representing pulses at the electrode locations, between spatially spaced electrodes,...

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Abstract

A system and method for cardiac resynchronization therapy ("CRT"] in which a model of baseline cardiac electrical activity, such as a model of global baseline cardiac electrical activity derived from various surface electrocardiograph ("ECG") signals, is utilized to automatically adjust pacing control parameters of a cardiac implantable electrical device ("CIED") are provided. The baseline model is modified with simulated pacing control parameters in an iterative fashion until ventricular electrical asynchrony is minimized. The simulated pacing control parameters resulting in the minimum ventricular electrical asynchrony are used to generate an updated model of ventricular activation, and this updated model is used to generate control parameters for the CIED using a QRS glyph morphological framework.

Description

[0001] Cross References to Related Applications [0002] This application requires the submission on February 1, 2011 and is called "Integration of Ventricular Activation Simulations and Surface ECG Registration with System and Methods for Automatically Generating Ventricular Activation Wavefront Fusion During Multisite Pacing Therapy" Ventricular Activation Simulation and Surface ECG Recording Integrated with System and Method for Automatically Generated Fusion of Ventricular Activity Waves)" in the interest of U.S. Provisional Patent Application Serial No. 61 / 462,366. Background of the invention [0003] The field of the invention is systems and methods for cardiac rhythm management. More specifically, the present invention relates to systems and methods for performing cardiac resynchronization therapy, in which cardiac electrical activity models, such as simulated and derived global cardiac electrical activity models, are automatically made For the adjustment of pacing con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/362A61N1/365A61B5/0402A61B5/0452A61N1/05G16H20/30G16H40/60
CPCG06F19/3481A61B5/04028A61N1/36592G06F19/3437A61B5/0452A61B5/4836A61N1/36585A61N1/3627G16H50/50G16H40/60G16H20/30A61B5/327A61B5/349
Inventor M·O·斯维尼
Owner THE BRIGHAM & WOMEN S HOSPITAL INC
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