Method for preparing colon-cleansing particles used before gynecological surgery

Abstract

The invention discloses a method for preparing colon-cleansing particles used before gynecological surgery and aims to solve the treatment problem before gynecological surgery. The method is characterized in that the colon-cleansing particles are prepared by the following active pharmaceutical ingredients: by weight proportion, horseweed herb, fructus cinnamomi, radix ranunculi ternati, Chinese starjasmine stem, herbof denseflower bulbophyllum, rhizoma polygonati, dipsacus roots, tangerine peel, sunflower flowers, turbo cornutus solander, amblystegium serpens and magnesium sulfate. The method includes the following steps: (1), extracting volatile oil from dipsacus roots, fructus cinnamomi and herbof denseflower bulbophyllum coarse powder for standby use; (2), smashing turbo cornutus solander and amblystegium serpens into fine powder for standby use; (3), adding water in horseweed herb, radix ranunculi ternati, Chinese starjasmine stem, rhizoma polygonati, sunflower flowers and tangerine peel for decoction twice, filtering, combining filtrate, concentrating the filtrate, adding ethanol for deposition, taking supernate, recycling ethanol and concentrating to obtain thick paste; (4), adding the volatile oil obtained in step 1 and the fine powder and magnesium sulfate obtained in step 2 in the thick paste obtained in step 3, uniformly stirring, forming particles, drying and obtaining the colon-cleansing particles. Clinical experiments show that the colon-cleansing particles have good colon-cleansing effect when used before gynecological surgery, and the colon-cleansing particles are worthy of clinical popularization and application.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a method for preparing intestinal-clearing granules used before gynecological operations. Background technique [0002] Bowel preparation before gynecological surgery includes stimulating intestinal peristalsis, softening and clearing feces, eliminating intestinal gas, and preventing patients from increasing the chance of contamination due to anal sphincter relaxation after anesthesia that cannot control defecation; at the same time, reducing intestinal gas filling and the impact of feces Surgical operation. Clinical practice has proved that oral cleansing of the mixed water decoction of rhubarb, Glauber's salt, and licorice can also reduce abdominal distension and discomfort after surgery. The traditional method is to take a residue-free liquid diet one day before the operation, take a laxative (such as: mannitol) orally in the evening before the operation, and clean the enema with 0.2...

AI Technical Summary

Problems solved by technology

This intestinal preparation method has the following defects: ①Mannitol is a hypertonic dehydrating agent, which strongly stimulates the intestinal tract and has a significant impact on the operator’s mood and sleep state; ②The last enema time of the traditional method is 6 am in the morning of the operation Entering the operating room at 8 am, during which there is not enough time for the intestinal tract to be completely emptied, and it is easy to cause pollution during the operation; ③It does not have a beneficial effect on postoperative recovery

[0003] At present, it is also reported to use traditional Chinese medicine preparations for preoperative bowel cleansing, such as oral administration of the above-mentioned rhubarb, mirabilite, and licorice mixed water decoction, but most of the drugs used are rhubarb and other laxative drugs, which are highly irritating after taking them. Mood and sleep state are significantly affected, and laxatives such as Baiziren are not easy to control the time of laxative

Therefore, there is a lack of a drug that is suitable for preoperative bowel cleansing, effective laxative and does not affect sleep, and can have a beneficial effect on postoperative recovery.