Method for administrating preparations containing peramivir and/or derivatives thereof
A drug delivery method and a technology of derivatives, which are applied in the field of neuraminidase inhibitors to treat influenza, can solve the problems of no significant reduction in sensitivity of peramivir and failure to do so, and prolong drug action time and residence time Long-lasting, fast-acting effects
Inactive Publication Date: 2013-12-18
陈永奇 +2
View PDF4 Cites 14 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
A 2011 study reported that new strains of swine flu emerging in Asia had developed some resistance to Roche's Tamiflu and GSK's Reganza without significantly reducing susceptibility to peramivir
However, due to great di
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Example Embodiment
[0047] Example 1: Inhalation of 1 mg peramivir metered dose inhaler
[0048] Component
[0049] Peramivir
Example Embodiment
[0052] Example 2: Inhalation of a 2 mg peramivir metered dose inhaler
[0053] Component
Example Embodiment
[0054] Example 3: Inhalation of 5 mg Peramivir metered dose inhaler
[0055] Component
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more PUM
| Property | Measurement | Unit |
|---|---|---|
| Particle size | aaaaa | aaaaa |
Login to view more
Abstract
The invention relates to a method for administrating preparations containing peramivir and/or derivatives thereof. Administration is carried out through inhalation. The method can be used for treating cold caused by influenza viruses. By adopting the administration method provided by the invention, not only can dependence on the single variety of drugs such as oseltamivir and zanamivir be reduced and new drug resistant virus strains generated by using the single variety in quantity be avoided but also the method which is favorable for greatly improving the bioavailability compared with oral administration or intravenous drip is provided for peramivir and/or derivatives thereof; more importantly, the method which has the advantages of small drug dose, less side effects and high effect taking speed is provided.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to (1S, 2S, 3S, 4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxyl-cyclo Pentyl-1-carboxylic acid (C 15 h 28 N 4 o 4 : peramivir) and derivatives thereof such as pharmaceutically acceptable salts, esters, hydrates or amorphous compounds as neuraminidase inhibitors, through direct respiratory administration of lung targets for the treatment of influenza. Background technique [0002] As we all know, influenza (Influenza) is an acute respiratory infectious disease caused by influenza virus. It is highly contagious and has a high incidence rate, which can easily cause outbreaks or pandemics. [0003] According to the World Health Organization (WHO), the outbreak of H7N9 bird flu in 2013 had infected 132 people as of May 30, of which 37 died, with a mortality rate as high as 28%. The H1N1 swine flu (Swine Flu) epidemic from 2009 to 2010 has laboratory-confirm...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more Application Information
Patent Timeline
Login to view more IPC IPC(8): A61K9/12A61K31/196A61P31/16A61P11/00
CPCA61K9/0075A61K9/0078A61K9/008A61K31/196A61P11/00A61P31/16
Inventor 陈永奇白仲虎丁玉龙张懿齐涛
Owner 陈永奇
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Try Eureka
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap