Preparation method for effective fraction of anti-osteoporosis cornus officinalis

Abstract

The invention provides a preparation method of an effective fraction of anti-osteoporosis cornus officinalis, and relates to the preparation method of an anti-osteoporosis drug. The effective fraction of the anti-osteoporosis cornus officinalis and the preparation method thereof aim to solve the problem that most of existing drugs used for treating osteoporosis are Western medicine which have many side effects on human bodies and are not good in treatment effect. The preparation method includes the steps of (1) after weighing cornus officinalis, decocting and concentrating the cornus officinalis to obtain concentrated medical liquid, (2) carrying out water extraction by alcohol sedimentation to obtain water-extraction alcohol-sedimentation concentrated liquid, (3) preprocessing macroporous resin to obtain a resin column, (4) enabling the water-extraction alcohol-sedimentation concentrated liquid to pass through the resin column and to be eluted through ethyl alcohol so as to obtain elution liquid, and (5) carrying out vacuum distillation and recycling the step (4) so as to obtain the ethyl alcohol in the elution liquid, carrying out concentration, and finally carrying out hypobaric drying to obtain the effective fraction of the cornus officinalis.

Description

technical field

[0001] The invention relates to a preparation method of an anti-osteoporosis medicine. Background technique

[0002] Osteoporosis is one of the most prevalent diseases in patients over middle age and represents the most prevalent public health problem, affecting more than 50% of postmenopausal women and more than 20% of men over the age of 50. Worldwide, more than 200 million people suffer from osteoporosis, including 75 million in Europe, Japan and the United States. Osteoporosis causes more than 1.5 million hip, spine and wrist fractures each year. Osteoporotic fractures can result in high mortality, high disability rates, and reduced mobility and quality of life. More than 50% of women with hip fractures require assistive devices for activities of daily living, 20% of them die within a year, and a significant number require long-term care. The aging population will inevitably increase the burden of osteoporosis and fractures for a long time to come. Gi...

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