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Preparation method for effective fraction of anti-osteoporosis cornus officinalis

An anti-osteoporosis, effective part technology, applied in medical preparations containing active ingredients, bone diseases, pharmaceutical formulations, etc. The effect of high sex and reducing bone resorption

Active Publication Date: 2015-06-17
王喜军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the existing medicines for treating osteoporosis are mainly western medicines, but the western medicines have large side effects on the human body and the treatment effect is not good, and provide a preparation method of effective parts of Cornus officinalis for anti-osteoporosis

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  • Preparation method for effective fraction of anti-osteoporosis cornus officinalis
  • Preparation method for effective fraction of anti-osteoporosis cornus officinalis
  • Preparation method for effective fraction of anti-osteoporosis cornus officinalis

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specific Embodiment approach 1

[0029] Specific Embodiment 1: The anti-osteoporosis effective fractions of Cornus officinalis in this embodiment are made of Cornus officinalis as a raw material, and the effective fractions of the total iridoid glycosides with a mass fraction of 85% to 95% are prepared by using macroporous adsorption resin technology Group, wherein the mass fraction of morroniside in the total iridoid glycosides is 40%-65%, and the mass fraction of loganin is 15%-30%.

specific Embodiment approach 2

[0030] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the mass fraction of morroniside in the total iridoid glycosides is 55% to 65%, and the mass fraction of loganin is 16% to 65%. 30%. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0031] Specific embodiment three: the preparation method of the anti-osteoporosis effective fractions of Cornus officinalis in this embodiment is carried out according to the following steps:

[0032] 1. Weigh the medicinal material of Cornus officinalis, then add water with a mass of 5 to 7 times the mass of the medicinal material of Cornus officinalis for decoction, decoct 1 to 3 times, decoct for 1.5h to 2.5h each time, separate the decoction liquid after each decoction and medicinal dregs, collect the decoction, and then decoct the obtained medicinal dregs for the next decoction, combine each decoction and let stand for 20h to 24h, then filter with gauze under normal pressure to obtain the filtrate. Under the condition of 60-80°C, concentrate under reduced pressure to a relative density of 1.10-1.30 to obtain a concentrated medicinal solution;

[0033] 2. Add ethanol with a volume concentration of 70% to 85% to the concentrated medicinal solution obtained in step 1 to make...

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Abstract

The invention provides a preparation method of an effective fraction of anti-osteoporosis cornus officinalis, and relates to the preparation method of an anti-osteoporosis drug. The effective fraction of the anti-osteoporosis cornus officinalis and the preparation method thereof aim to solve the problem that most of existing drugs used for treating osteoporosis are Western medicine which have many side effects on human bodies and are not good in treatment effect. The preparation method includes the steps of (1) after weighing cornus officinalis, decocting and concentrating the cornus officinalis to obtain concentrated medical liquid, (2) carrying out water extraction by alcohol sedimentation to obtain water-extraction alcohol-sedimentation concentrated liquid, (3) preprocessing macroporous resin to obtain a resin column, (4) enabling the water-extraction alcohol-sedimentation concentrated liquid to pass through the resin column and to be eluted through ethyl alcohol so as to obtain elution liquid, and (5) carrying out vacuum distillation and recycling the step (4) so as to obtain the ethyl alcohol in the elution liquid, carrying out concentration, and finally carrying out hypobaric drying to obtain the effective fraction of the cornus officinalis.

Description

technical field [0001] The invention relates to a preparation method of an anti-osteoporosis medicine. Background technique [0002] Osteoporosis is one of the most prevalent diseases in patients over middle age and represents the most prevalent public health problem, affecting more than 50% of postmenopausal women and more than 20% of men over the age of 50. Worldwide, more than 200 million people suffer from osteoporosis, including 75 million in Europe, Japan and the United States. Osteoporosis causes more than 1.5 million hip, spine and wrist fractures each year. Osteoporotic fractures can result in high mortality, high disability rates, and reduced mobility and quality of life. More than 50% of women with hip fractures require assistive devices for activities of daily living, 20% of them die within a year, and a significant number require long-term care. The aging population will inevitably increase the burden of osteoporosis and fractures for a long time to come. Gi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/40A61P19/10
Inventor 王喜军张爱华孙晖
Owner 王喜军
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