Zedoary oil injection and preparation method thereof
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A technology of turmeric oil and injection, which is applied in the field of turmeric oil injection and its preparation, and can solve problems such as unsatisfactory clarity.
Active Publication Date: 2013-12-25
张蕊 +2
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[0003] The patent application with application number 201310194657.1 discloses a kind of zedoary oil injection and its preparation method. Zedoary oil injection made of zedoary ester, referred to as HS15) as a solubilizer is safer than the commercially available Zedoary oil injection, but its clarity is not ideal
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Embodiment 1
[0020] Example 1 It is prepared from 10.0g / L zedoary oil, 80.0g / L HS15, 30.0ml / L ethanol and water for injection. (Specification: 10ml: 0.1g) (with activated carbon)
[0021] Take 10.0g zedoary oil, add 80gHS15, stir evenly; slowly add 30.0ml ethanol, stir evenly; take an appropriate amount of water for injection at 30°C ~ 40°C, add slowly, stir while adding, and stir evenly when the volume reaches 1000.0ml; add 0.2g of activated carbon, stir evenly and let it stand for 30 minutes; adjust the pH value to 4.53 with 1.0mol / L hydrochloric acid, filter until the clarity is acceptable, and then potting.
Embodiment 2
[0022] Example 2 It is prepared from 10.0g / L zedoary oil, 80.0g / L HS15, 30.0ml / L ethanol and water for injection. (Specification: 10ml: 0.1g) (without activated carbon)
[0023] Take 10.0g of zedoary oil, add 80gHS15, stir evenly; slowly add 30.0ml of ethanol, stir evenly; take an appropriate amount of water for injection at 30℃~40℃, slowly add, stir while adding, and then dilute to 1000.0ml; use 1.0mol / L hydrochloric acid to adjust the pH value to 4.58, filter until the clarity is qualified, and then potting, to obtain.
Embodiment 3
[0024] Example 3 It is prepared from 10.0g / L zedoary oil, 50.0g / L HS15, 100.0ml / L ethanol and water for injection. (Specification: 10ml: 0.1g) (with activated carbon)
[0025] Take 10.0g zedoary oil, add 50gHS15, stir evenly; slowly add 100.0ml ethanol, stir evenly; take an appropriate amount of water for injection at 30°C ~ 40°C, slowly add, stir while adding, set the volume to 1000.0ml, stir evenly, add 0.2g of activated carbon, stir evenly and let it stand for 30 minutes; adjust the pH value to 4.41 with 1.0mol / L hydrochloric acid, filter until the clarity is acceptable, and then potting.
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Abstract
The invention discloses zedoary oil injection and a preparation method thereof. The zedoary oil injection mainly comprises the following components: (1) zedoary oil serving as an active component, (2) 15-hydroxystearic acid macrogol ester (also known as polyethylene glycol-12- hydroxystearic acid ester, and called HS-15 for short) serving as a solubilizing agent, (3) alcohol serving as a cosolvent, and (4) injection for water serving as a solvent. Compared with commercially available injection, the zedoary oil injection has the advantages that the product prepared by adopting a bran-new prescription and technology is in line with the pharmacopoeia criterion for the zedoary oil injection and the safety of clinical medication of the product is also greatly improved.
Description
technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a zedoary oil injection and a preparation method thereof. Background technique [0002] Zedoary oil is derived from the volatile oil extracted from the rhizomes of Zingiberaceae Curcuma and Curcuma. Modern medical research has confirmed that Zedoary oil has anti-virus, anti-bacterial, anti-tumor, anti-thrombosis, liver protection, treatment of psoriasis, cervical erosion, digestive Wide range of pharmacological activities such as ulcers and immune enhancement. Zedoary oil injection is often used clinically as an antiviral drug. From 1988 to July 2004, 221 cases of Zedoary oil injection were reported in the case report database of the National Center for Adverse Drug Reaction Monitoring. In the case reports, the age of patients is mainly concentrated in children under 10 years old, accounting for 62.4%; the main reason for medication is respiratory tract infec...
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