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A kind of preparation method and application of Xiao'er Qingre tablet
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A technology for Xiaoer Qingre tablets and small cell lung cancer, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc., can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage
Active Publication Date: 2015-08-05
西安市新龙药业有限公司
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[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Xiaoer Qingre Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this product
Method used
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Embodiment 1
[0016] Take 117.6g Phellodendron Phellodendron, 23.5g Rush, 117.6g Gardenia, 47g Uncaria, 47g Realgar, 70.6g Coptis, 23.5g Cinnabar, 47g Gentiana, 117.6g Scutellaria, 47g Rhubarb, and 0.47g Peppermint Oil and add them to CO2 supercritical extraction In the device, ethanol is used as entrainer, the volume percentage of entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain a supercritical extract, adding starch , 70% ethanol granules, dried, compressed into 500 tablets, each weighing 0.5g.
Embodiment 2
[0018] Take Phellodendron 117.6g, rush 23.5g, gardenia 117.6g, Uncaria 47g, realgar 47g, coptis 70.6g, cinnabar 23.5g, gentian 47g, scutellaria baicalensis 117.6g, rhubarb 47g, and peppermint oil 0.47g into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.
Embodiment 3
[0020] Take Phellodendron 117.6g, rush 23.5g, gardenia 117.6g, Uncaria 47g, realgar 47g, coptis 70.6g, cinnabar 23.5g, gentian 47g, scutellaria baicalensis 117.6g, rhubarb 47g, and peppermint oil 0.47g into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.
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Abstract
The invention provides a preparation method of infant heat-clearing tablets. The infant heat-clearing tablets are prepared from the following raw materials: 117.6 g of golden cypress, 23.5 g of juncus communis, 117.6 g of jasmine, 47 g of uncaria, 47 g of realgar, 70.6 g of coptis chinensis, 23.5 g of cinnabar, 47 g of radix gentianae, 117.6 g of scutellaria baicalensis, 47 g of rheum officinale and 0.47 g of dementholized peppermint oil. The infant heat-clearing tablets are prepared with a supercritical extraction method, so that the content is greatly increased and the dosage is reduced. The invention further provides an application of the infant heat-clearing tablets to preparation of drugs for inhibiting cell proliferation of a small cell lung cancer SCLC.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Xiaoer Qingre Tablet. Background technique [0002] Xiaoer Qingre Tablets is recorded in the Pharmacopoeia, and the prescription is Phellodendron 117.6g, Rush 23.5g, Gardenia 117.6g, Uncaria 47g, Realgar 47g, Coptis 70.6g, Cinnabar 23.5g, Gentian 47g, Scutellaria baicalensis 117.6g, Rhubarb 47g, Peppermint oil 0.47g, the above eleven flavors, in addition to peppermint oil, cinnabar and realgar are separately water-flyed into fine powder, Coptidis rhubarb and rhubarb are crushed into fine powder; Phellodendri cypress and Gentiana are infiltrated with 70% ethanol, the filtrate is collected, and ethanol is recovered. Concentrate into a thick paste; add the remaining rushes and other four flavors to decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate into a thick paste. ...
Claims
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