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Preparation method for Sanhuang tablet

The technology of Sanhuang Tablets and Rhubarb is applied in the field of preparation of Sanhuang Tablets, which can solve the problems of large dosage, inconvenient taking, and many impurities for patients, and achieve the effect of reducing dosage.

Inactive Publication Date: 2014-01-22
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Sanhuang Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, seriously affecting the quality of life. This product is used clinically

Method used

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  • Preparation method for Sanhuang tablet

Examples

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Effect test

Embodiment 1

[0016] Take 300g of rhubarb, 5g of berberine hydrochloride, and 80g of Scutellaria baicalensis extract into a CO2 supercritical extractor, use ethanol as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and CO2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 300g of rhubarb, 5g of berberine hydrochloride, and 80g of Scutellaria baicalensis extract into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 300g of rhubarb, 5g of berberine hydrochloride, and 80g of Scutellaria baicalensis extract into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 Flow rate 2m1 / g crude drug min, extraction time 160min, get supercritical extract, add starch, 70% ethanol to make granules, dry, compress into tablets, make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method for a Sanhuang tablet. The Sanhuang tablet is prepared from the bulk drugs consisting of 300 g of rhubarb root and rhizome, 5 g of berberine hydrochloride and 80 g of baical skullcap root extract through supercritical extraction, so the content of Sanhuang tablet is greatly increased, and the dose of the Sanhuang tablet is reduced. The invention further provides application of the Sanhuang tablet in preparation of drugs used for inhibiting cell proliferation of human large cell carcinoma NCI-H460.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Sanhuang tablets. Background technique [0002] Sanhuang tablets are recorded in the Pharmacopoeia. The prescription is 300g of rhubarb, 5g of berberine hydrochloride, 21g of baicalin extract (equivalent to 15g of baicalin). 1 hour for the second time, 40 minutes for the third time, combine the decoction, filter, add hydrochloric acid to the filtrate to adjust the pH value to 1-2, let it stand for 1 hour, take the precipitate, wash with water to make the pH value to 5-7, and dry , crushed into fine powder, assayed for content, and set aside. Take 150g rhubarb, crush it into fine powder, and sieve; the remaining rhubarb is crushed into coarse powder, add 30% ethanol to reflux and extract three times, filter, combine the filtrate, recover ethanol and concentrate under reduced pressure to a thick paste, add r...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/20A61P11/00A61P35/00A61K31/4375
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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