Magnetic-field fluidized bed micro-capsule-loaded artificial liver reactor

Abstract

The invention discloses a magnetic-field fluidized bed micro-capsule-loaded artificial liver reactor. The magnetic-field fluidized bed micro-capsule-loaded artificial liver reactor comprises a fluidized bed reactor loaded with micro-encapsuled liver cells, and magnetic medium particles are embedded inside the micro-capsules, under the action of an external magnetic field, exert magnetic-field force opposite to the fluid drag force in direction on the micro-capsules, significantly increase the entrainment speed of the micro-capsules, which is generated by the fluid, and maintains the suspension state of the micro-capsules inside the reactor within a relatively large flow speed range. Therefore, the problems of low operation flow speed and large reactor design size due to the fact that the micro-capsules are small in proportion and size and easy to be driven out by fluid of the micro-capsule-fluidized bed reactor; substance mixing and exchange can be well achieved under relatively higher flow speed and relatively higher liver cell density, further the therapeutic effects of an artificial liver can be maximized. Besides, by adjusting the intensity of the magnetic field, controllable and stable fluidization under different fluid viscosities and different fluid densities can be obtained.

Description

technical field [0001] The invention relates to a medical device, in particular to a core device of a bioartificial liver or hybrid artificial liver support system for the clinical treatment of acute liver failure: a magnetic field fluidized bed-loaded microcapsule artificial liver reactor. Background technique [0002] Artificial liver support system is an extracorporeal mechanical or physical and chemical device that temporarily assists or completely replaces the function of the failed liver, removes various harmful substances, compensates for the metabolic function of the liver, and helps patients recover and regenerate the liver or bridge the transition to liver transplantation. . The bioartificial liver loaded with highly active liver cells can effectively perform liver synthesis, transformation and other functions, which is the future development direction of artificial liver. The bioreactor is the core component of the bioartificial liver, and its basic requirements ...

AI Technical Summary

Problems solved by technology

It can be seen that the ideal microcapsule-loaded artificial liver reactor should be able to meet the high plasma flow rate and have a small design volume. Although the microcapsule-fixed bed reactor and the microcapsule fluidized bed reactor have their own advantages, they are None of them can fully meet the above requirements, so it is necessary to develop a new type of reactor and artificial liver system, which has a high cell loading density and a small reactor design volume; has a high plasma flow rate, and can achieve good cell and plasma (blood) Substance exchange provides liver cells with sufficient nutrients (including oxygen), and the functional molecules secreted by liver cells can enter the plasma (blood) in time to play a role; it can maintain cell growth and metabolic activity for a long time; it can protect cells from shearing and immunity, etc.

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