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Beneficial active agents for preventing and/or treating dandruff conditions of the scalp

A disease and bacterial technology, applied in the field of active agents for dandruff diseases, can solve the problems of aggravating dandruff symptoms, the impact of dandruff active agents, and slowing down the development of dandruff

Inactive Publication Date: 2018-05-25
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the aggressiveness of some anti-dandruff active agents with respect to epidermal cells or scalp bioflora can also affect the barrier function of the scalp and lead to aggravated dandruff conditions
Finally, the efficacy of anti-dandruff treatments is often slow to develop and requires rigorous application in the long term
This lag time often results in non-adherence to treatment
Therefore, many failures occur in the use of these treatments

Method used

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  • Beneficial active agents for preventing and/or treating dandruff conditions of the scalp
  • Beneficial active agents for preventing and/or treating dandruff conditions of the scalp
  • Beneficial active agents for preventing and/or treating dandruff conditions of the scalp

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Preparation of the active agent according to the invention

[0169] The complete fermentation medium was prepared by culturing the strain of Vitiligo linearis in its complete medium.

[0170] The initial medium used to obtain the complete fermentation medium had the composition described in Table 1 below.

[0171] Table 1

[0172]

[0173]

[0174] In order to obtain the cosmetic active agent according to the invention, ie in this example the lysate of Vitiligo vitratus in complete fermentation medium, the method as described below was carried out.

[0175] A strain of Vibriella linearis (strain 15551 ) was obtained from the ATCC. The strain was cultivated in a specific medium 2BHG2, the composition of which was given above.

[0176] Biomass was obtained by continuous cultivation in a bioreactor with a working capacity of 3000 liters. A growth rate of about 70% of μmax (μ=0.12H-1) was recorded during the continuous production phase. During this step, pH (...

Embodiment 2

[0187] In Example 2, (i) shampoos comprising an anti-dandruff active agent according to the invention (a lysate of Vitiligo vibriella bacteria in a complete fermentation medium prepared according to Example 1) were compared Effect of formulations and (ii) reference anti-dandruff shampoo formulations without anti-dandruff active agents according to the invention and comprising conventional anti-dandruff active agents (ZnPT) on dandruff conditions of the scalp.

[0188] Therefore, the lysate of the bacteria in the complete fermentation medium obtained in Example 1 (anti-dandruff active agent according to the invention) was used as anti-dandruff active agent in shampoo formulations, which The basic composition of the dosage formulation is described in Table 2 below.

[0189] Several clinical studies have been conducted,

[0190] Clinical Study 1, corresponding to figure 1 ,

[0191] Clinical Study 2, corresponding to figure 2 ,

[0192] Clinical Study 3, corresponding to ...

Embodiment 3

[0241] Negative MIC data for indicating no antifungal effect

[0242] The test product is exposed to the Malassezia suspension. This mixture was deposited on the surface of the agar medium. The mixture was spread out and excess mixture was recovered prior to incubation. Cultivation was continued for at least 5 days at 30°C.

[0243] Products were placed in liquid modified Leeming and Notman medium (LNm) and tested in duplicate. The complete culture was 7.5 g / l or 150 g / l (concentrated form) based on dry matter.

[0244] Complete cultures were tested at 10% (for a concentration at 7.5 g / l) and 1% (for a concentration at 150 g / l).

[0245] The positive reference was 1% zinc pyrithione.

[0246] The solution of the product was concentrated twice to allow for dilution to 1 / 2 during contact with the Malassezia suspension.

[0247] Table 4

[0248]

[0249] M. globosa and M. restrictis strains were collected on agar slants and subcultured at 30° C. and grown until tested...

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Abstract

The present invention relates to the cosmetic use of a bacterial lysate of bacteria of the genus Hyaline, in particular the species: Hyaline, in a complete fermentation medium as an active agent for the prevention and / or treatment of dandruff conditions of the scalp, The dandruff condition includes a dandruff condition on the scalp associated with the prevalence of pathogenic microorganisms on the scalp and / or an imbalance in the ecological flora of the scalp.

Description

technical field [0001] The present invention relates to the cosmetic use of active agents derived from microorganisms of the genus Vitreoscilla (especially species: Vitreoscilla filiformis) as active agents for the prevention and / or treatment of dandruff disorders of the scalp, The dandruff condition includes a dandruff condition associated with the proliferation of pathogenic microorganisms on the scalp and / or an imbalance of the ecological flora of the scalp. Background technique [0002] Skin is a tissue in which cells are connected together and integrally attached to each other. Skin tissue forms the outer layer including the sebaceous or sweat glands and hair follicles. The skin, especially the scalp, is an epidermis that undergoes continuous regeneration. Regeneration or desquamation is a coordinated and finely regulated process that results in the imperceptible and invisible removal of superficial cells. [0003] However, abnormal or irregular shedding of the cells...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/99A61Q5/00
CPCA61K8/99A61K2800/70A61K2800/74A61K2800/85A61Q5/006A61K35/74
Inventor 帕斯卡·希莱尔杨·马希理查德·马丁
Owner LOREAL SA
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