A preparation method of polysaccharide iron complex and its quality detection method

A complex and polysaccharide iron technology, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve problems such as unsatisfactory production yields

Active Publication Date: 2017-07-07
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The currently disclosed preparation process for the production of polysaccharide iron is not ideal for the improvement of production yield, so it is necessary to study and improve the process of polysaccharide iron complex

Method used

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  • A preparation method of polysaccharide iron complex and its quality detection method
  • A preparation method of polysaccharide iron complex and its quality detection method
  • A preparation method of polysaccharide iron complex and its quality detection method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0064] Experimental Example 1 Optimum Reaction Condition Determination Experiment

[0065] The experiment was designed by orthogonal design to determine the optimal reaction conditions. Five factors were selected: A. The amount of sodium carbonate, expressed in grams of 0.2 (W / W) sodium carbonate aqueous solution; B. The concentration of ferric chloride aqueous solution, expressed in terms of the amount of water used to dissolve ferric chloride Indicates, in grams; C. The temperature in the reactor when sodium carbonate is added, ℃; D. The temperature in the reactor when sodium hydroxide is added, ℃; E. The reaction time required for adding sodium carbonate, minutes, choose L 16 (2 15 ) orthogonal table, the table header is as follows:

[0066] Table 1 Orthogonal design header (L 16 (2 15 ))

[0067]

[0068] The selected assessment index is the iron output, which is the product of the polysaccharide iron amount obtained by the reaction and its iron content, i.e. W pro...

experiment example 2

[0079] Experimental example 2 detailed preparation method and its basis experiment

[0080] Using the preparation method described in Example 1, Table 6 provides the proportioning and product yield of each material, from which the material balance of the process can be carried out. As seen from Table 6, it is 40% relative to the product mass yield of ferric chloride. The reaction steps are few, the reaction conditions are relatively mild, and it is easy to master. As long as the ingredients and operating conditions are followed, the yield can be achieved, and most of the impurities can be easily removed by precipitation and centrifugation. In the preparation method of the present invention, the polysaccharide-iron complex is washed twice to wash away the remaining uncomplexed ferric ions and polysaccharides, and remove the contained chloride ions and sodium ions at the same time, and the impurity content is already small .

[0081] Table 6 Process conditions, material ratio ...

experiment example 3

[0085] Experimental Example 3 The control of the first alkali dropwise addition of the polysaccharide-iron complex of the present invention

[0086] In production research engineering, the yield of polysaccharide-iron complex is sometimes high, sometimes low, and sometimes even the final product cannot be obtained. After a lot of experimental research, it was unexpectedly found that the control of the first addition of lye is a key link. If the addition is too fast or excessive, the polysaccharide-iron complex cannot be formed later. After a large number of experiments, it was found that 700-1100 parts by weight of 20% sodium carbonate aqueous solution was added to the reaction tank within 60-90 minutes (preferably 85, 65, and 70 minutes), and the reaction temperature was controlled at 0-10°C (preferably 3-9°C, 6°C, 4°C, 8°C), after the feeding is completed, continue to stir for 15-30 minutes, after the stirring is completed, the reaction solution is raised to room temperature...

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Abstract

The invention discloses a preparation method of a polysaccharide-iron complex and a quality detection method thereof. The preparation method is as follows: adding ferric chloride aqueous solution and syrup into a reaction tank and stirring, dissolving with alkali solution, stirring and stabilizing complexing with iron ions to form polysaccharide iron complexes, centrifuging, washing and drying. The preparation method has few reaction steps, mild reaction conditions, good reproducibility, reliable process conditions and operability; and no harmful gas is generated in the reaction. The method for determining the content of the polysaccharide-iron complex has high accuracy, good precision, strong specificity and durability, meets the requirement of linearity, and is accurate, sensitive and simple.

Description

technical field [0001] The invention relates to a preparation method of a complex and a quality detection method thereof, in particular to a preparation method of a polysaccharide-iron complex and a quality detection method thereof. Background technique [0002] Iron deficiency anemia is the most common anemia disease in the world, especially in children and women. Due to the increased demand for iron, the body is often in a state of iron deficiency. Iron deficiency in pregnant women makes the incidence of intrauterine growth retardation, deformity and death obvious Increase. [0003] The most important way to prevent iron deficiency anemia is to add enough iron to the body. Currently clinically commonly used iron preparations include ferrous sulfate, ferrous succinate, and ferrous gluconate. These iron preparations produce free iron ions in the digestive tract, which can stimulate the stomach and intestinal mucosa, and are prone to nausea, vomiting, and diarrhea. , abdomi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H3/06C07H1/00C08B37/00G01N21/78G01N31/16A61P7/06
Inventor 王京端展莜林姜作玲张朋言
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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