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A kind of vitamin C tablet and preparation method thereof

A technology of vitamins and microcrystalline cellulose, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, and devices for making drugs into special physical or ingestible forms, which can solve the problems affecting the quality of preparations, color changes, and content decline. And other issues

Active Publication Date: 2016-03-23
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because vitamin C has an enediol structure in its molecular structure, it is prone to oxidative degradation reactions, making its color change and content decrease, which will affect the quality of the preparation

Method used

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  • A kind of vitamin C tablet and preparation method thereof
  • A kind of vitamin C tablet and preparation method thereof
  • A kind of vitamin C tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The drug formulation consists of:

[0056] The main drug is 100g (vitamin C), and the excipients are 36.3g; the mass percentages of the excipients are: 60% dextrin, 1% starch, 1% tartaric acid, 1% magnesium stearate, 20% sodium starch glycolate, 5.5% talcum powder, Silicon oxide 0.5%, hypromellose 1%, microcrystalline cellulose 10%.

[0057] Preparation:

[0058] (1) Weigh dextrin, starch, sodium starch glycolate, hypromellose, microcrystalline cellulose and lubricant according to the formula and pass through 80-mesh sieve respectively;

[0059] (2) adding tartaric acid to 70% by mass ethanol and dissolving it into a 5% tartrate alcohol solution by mass;

[0060] (3) Add hypromellose to 70% by mass ethanol and dissolve it into a solution with a concentration of 10% by mass, which is the wetting agent, and set aside;

[0061] (4) Mix dextrin, starch, microcrystalline cellulose and vitamin C raw materials which account for 40% of the total amount of microcrystalline ce...

Embodiment 2

[0065] The drug formulation consists of:

[0066] The main drug is 100g (vitamin C), and the excipients are 36.3g; the mass percentages of the excipients are: dextrin 49.6%, starch 2.8%, tartaric acid 2.8%, magnesium stearate 3.6%, carboxymethyl starch sodium 16.5%, talcum powder 6.9%, di Silicon oxide 1.7%, hypromellose 2.4%, microcrystalline cellulose 13.7%.

[0067] Preparation:

[0068] (1) Weigh dextrin, starch, sodium starch glycolate, hypromellose, microcrystalline cellulose and lubricant according to the formula and pass through 80-mesh sieve respectively;

[0069] (2) adding tartaric acid to 50% by mass ethanol and dissolving it into a 2% tartrate alcohol solution by mass;

[0070] (3) Add hypromellose to 50% by mass ethanol and dissolve it into a solution with a concentration of 6% by mass, which is the wetting agent, and set aside;

[0071] (4) Mix dextrin, starch, microcrystalline cellulose and vitamin C raw materials evenly;

[0072] (5) Add the previously pre...

Embodiment 3

[0075] The drug formulation consists of:

[0076] The main drug is 100g (vitamin C), and the excipients are 36.3g; the mass percentages of the excipients are: dextrin 30%, starch 5%, tartaric acid 5%, magnesium stearate 5%, carboxymethyl starch sodium 15%, talcum powder 3%, di Silicon oxide 2%, hypromellose 5%, microcrystalline cellulose 30%.

[0077] Preparation:

[0078] (1) Weigh dextrin, starch, sodium starch glycolate, hypromellose, microcrystalline cellulose and lubricant according to the formula and pass through 80-mesh sieve respectively;

[0079] (2) adding tartaric acid to 45% by mass ethanol and dissolving it into a 1% tartrate-alcohol solution by mass;

[0080] (3) Add hypromellose to 45% by mass ethanol and dissolve it into a solution with a mass percent concentration of 1%, which is the wetting agent, and set aside;

[0081] (4) Mix dextrin, starch, microcrystalline cellulose and vitamin C raw materials which account for 60% of the total amount of microcrystal...

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Abstract

The invention provides a vitamin C tablet and a preparation method thereof. By changing the formula of auxiliary materials in the original production process, the stability of vitamin C tablets is effectively improved, and the quality problem of easy discoloration of vitamin C tablets during storage is solved. The proportion of auxiliary materials in the production process is: dextrin 30-60%, starch 1-5%, carboxymethyl starch sodium 10-20%, hypromellose 1-5%, microcrystalline cellulose 10-30%, tartaric acid 1 to 5%, and the balance is lubricant. The wetting agent used is 30-70% ethanol. The vitamin C tablet prepared by the invention has a smooth surface and stable performance, is suitable for large-scale production, and the product quality meets the requirements of the Chinese Pharmacopoeia.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a vitamin C tablet and a preparation method. Background technique [0002] Vitamin C tablets are non-prescription vitamin medicines. It can be used to prevent scurvy, and can also be used for adjuvant treatment of various acute and chronic infectious diseases and purpura. The drug is involved in the formation of antibodies and collagen in the body, tissue repair (including certain redox effects), metabolism of phenylalanine, tyrosine, and folic acid, utilization of iron and carbohydrates, synthesis of fat and protein, and maintenance of immunity. Function, hydroxylate serotonin, maintain the integrity of blood vessels, and promote the absorption of non-heme iron. For clinical commonly used drugs. [0003] Because vitamin C has an enediol structure in its molecular structure, it is prone to oxidative degradation reactions, resulting in color changes and content dec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/375A61P3/02A61P7/04A61J3/00
Inventor 李云仙叶亚斌段昆花李俊
Owner YUNNAN PHYTOPHARML