Traditional Chinese medicine composition for preventing chemoradiotherapy acute radioreaction

A radiation reaction and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of affecting curative effect, increased radiotherapy toxicity, increased radiotherapy mucosal damage, etc., and achieves good curative effect and no toxic and side effects

Active Publication Date: 2014-04-09
北京天潭中医医学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the curative effect of concurrent chemotherapy and radiotherapy is certain, the correlation and the increase of radiotherapy toxicity are also certain. Due to the increase of acute toxicity, the unplanned interruption of radiotherapy often affects the curative effect. At the same time, the additive effect of drug toxicity also affects the quality of life of patients, especially Although the current use of precise radiotherapy can reduce the damage of high-risk organs, the mucosal damage of radiotherapy will increase due to the dose relationship, especially the addition of chemotherapy will affect the operability of simultaneous radiochemical treatment of stage III / IV nasopharyngeal carcinoma

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1 oral liquid 1

[0078] 35g Shegan, 60g Coptidis Rhizoma, 30g Houttuynia cordata, 35g Zhimu, 30g Zhuru, 40g Agrimony, 40g Chrysanthemum, 30g Wintersweet, 30g Mulan, 35g Oxtail, 30g Goosegrass, 35g Baijiu, Yuanbao Grass 20g were crushed separately, mixed to obtain a mixture, added 3.6kg of water, soaked for 5 hours, distilled for 5 hours, collected volatile oil, and the dregs were used for later use, 60g of Acanthopanax, 75g of Codonopsis pilosula, 50g of Ligustrum lucidum, 30g of coix seed, and dendrobium 35g, madder 35g, angelica 25g, red peony 35g, curcuma 30g, selaginella 35g, heterophylla 40g, uncaria 35g, yam 25g, rhubarb 25g, jujube 25g and dodder 35g were crushed respectively, put into continuous extraction tank, Then add the medicinal residues obtained above, add 4kg of water to extract for 5 hours, filter the extract, concentrate to a relative density of 1.10 (60°C), let stand for 24 hours, take the supernatant to recover ethanol and concentrate to ...

Embodiment 2

[0079] Embodiment 2 oral liquid 2

[0080] Shegan 40g, Coptidis 65g, Houttuynia cordata 35g, Anemarrhena 40g, Zhuru 35g, Agrimony 45g, Chrysanthemum 40g, Wintersweet 30g, Mulan 30g, Oxtail 35g, Goosegrass 30g, Liquor grass 35g, Yuanbao Grass 20g were crushed separately, mixed to obtain a mixture, added 4kg of water, soaked for 5 hours, distilled for 5 hours, collected volatile oil, and the dregs for later use, 65g of Acanthopanax, 80g of Codonopsis, 55g of Ligustrum lucidum, 35g of coix seed, and 40g of dendrobium , madder 40g, angelica 25g, red peony root 35g, curcuma 30g, selaginella 35g, heterophylla 40g, uncaria 35g, Chinese yam 25g, rhubarb rhubarb 25g, jujube 25g and dodder 35g were crushed respectively, put into continuous extraction irrigation, and then Add the medicinal residues obtained above, add 4kg of water to extract for 5 hours, filter the extract, concentrate to a relative density of 1.10 (60°C), and stand still for 24 hours, take the supernatant to recover eth...

Embodiment 3

[0081] Embodiment 3 oral liquid 3

[0082] Shegan 35g, Coptidis 60g, Houttuynia cordata 30g, Anemarrhena 35g, Zhuru 30g, Agrimony 40g, Chrysanthemum 35g, Wintersweet 25g, Mulan 25g, Oxtail 30g, Goosegrass 25g, Liquor grass 30g, Yuanbao Grass 15g were crushed separately, mixed to obtain a mixture, added 3.6kg of water, soaked for 5 hours, distilled for 5 hours, collected volatile oil, and the dregs were used for later use, 60g of Acanthopanax, 75g of Codonopsis pilosula, 50g of Ligustrum lucidum, 30g of coix seed, and dendrobium 35g, madder 35g, angelica 20g, red peony 30g, curcuma 25g, selaginella 30g, heterophylla 35g, uncaria 30g, yam 20g, rhubarb 20g, jujube 20g and dodder 30g were crushed respectively, put into the continuous extraction tank, Then add the medicinal residues obtained above, add 4kg of water to extract for 5 hours, filter the extract, concentrate to a relative density of 1.10 (60°C), let stand for 24 hours, take the supernatant to recover ethanol and concent...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for preventing chemoradiotherapy acute radioreaction. The traditional Chinese medicine composition comprises the following raw materials: acanthopanax, codonopsis pilosula, glossy privet fruit, blackberry lily, semen coicis, dendrobe, rhizoma coptidis, cordate houttuynia, rhizoma anemarrhenae, madder, caulis bambusae in taeniam, hairyvein agrimony, angelica sinensis, root of common peony, chrysanthemum, curcuma zedoary, selaginella tamariscina, radix pseudostellariae, uncaria, Chinese yam, chimonanthus nitens, indigofera tinctoria, meadow fescue, eleusine indica, conyza japonica, hypericum sampsonii hance, dock root, Chinese date and semen cuscutae. The traditional Chinese medicine composition has good curative effect, has no toxic and side effects, can be used as adjuvant therapy medicine for chemoradiotherapy of tumors of nasopharynx cancer, can be synchronously used in chemoradiotherapy of patients of nasopharynx cancer, is extremely helpful for increasing chemoradiotherapy effect, reducing side effects after chemoradiotherapy and improving quality of life, and reveals good prospect for comprehensive treatment for malignant tumors.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition used for preventing acute radiation reaction of radiotherapy and chemotherapy. Background technique [0002] Nasopharyngeal carcinoma is a high incidence of head and neck tumors in southern my country and Asian Chinese. The etiology is related to factors such as Epstein-Barr virus infection, genetics, and environmental pollution. Radiation therapy is currently the first choice for effective treatment. The 5-10-year survival rate of nasopharyngeal carcinoma patients treated with single radiotherapy is only about 40%. The treatment of stage III / IV nasopharyngeal carcinoma has become a standard method to improve the curative effect. At present, platinum-based drug combination therapy is mostly used. The combination of radiotherapy and chemotherapy can improve the survival rate, reduce local recurrence and reduce the inc...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/48A61K9/08A61P39/02A61P1/14A61P35/00
Inventor 陈朝晖闫莉
Owner 北京天潭中医医学研究院
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