A kind of preparation method and application of Yulu Baofei pill

A technology of Yulu Baofei Pills and lymphoma cells, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulas. It can solve the problems of large dosage for patients, rough process, and impact on application, and achieve the goal of reducing dosage. Effect

Active Publication Date: 2016-04-20
山东一言本草生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Yulu Baofei Pills. However, the method of powdering is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. products in clinical application

Method used

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  • A kind of preparation method and application of Yulu Baofei pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 120g of Asparagus, 120g of Ophiopogon japonicus, 80g of Dendrobium, 80g of Rehmannia glutinosa, 80g of Rehmannia glutinosa, 40g of Zhimu, 40g of Cork and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and CO 2 Flow rate 1m1 / g crude drug·min, extraction time 150min, get supercritical extract, pulverize into fine powder, sieving, mixing, add 100g of refined honey per 100g powder to make big honey pill, ready to get, each pill weighs 4.5 g.

Embodiment 2

[0018] Take 120g of Asparagus, 120g of Ophiopogon japonicus, 80g of Dendrobium, 80g of Rehmannia glutinosa, 80g of Rehmannia glutinosa, 40g of Zhimu, 40g of Cork and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, the supercritical extract is obtained, crushed into fine powder, sieved, and mixed, 100g of refined honey is added per 100g of powder to make a big honey pill, which is ready, each pill weighs 4.5 g.

Embodiment 3

[0020] Take 120g of Asparagus, 120g of Ophiopogon japonicus, 80g of Dendrobium, 80g of Rehmannia glutinosa, 80g of Rehmannia glutinosa, 40g of Zhimu, 40g of Cork and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer. The entrainer accounts for 5% of the total extraction solvent. The extraction pressure is 20MPa, the temperature is 40°C, and CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, the supercritical extract is obtained, crushed into fine powder, sieved, and mixed, 100g of refined honey is added per 100g of powder to make a big honey pill, which is ready, each pill weighs 4.5 g.

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Abstract

The invention provides a preparation method of Yulu lung-protecting pills. The pills are prepared from active ingredients, namely, 120 g of radix asparagi, 120 g of radix ophiopogonis, 80 g of dendrobium nobile, 80 g of radix rehmanniae, 80 g of prepared rehmannia roots, 40 g of rhizome anemarrhenae and 40 g of amur cork tree bark through supercritical extraction, so that the content is increased greatly, and the dose is decreased. The invention further provides an application of the Yulu lung-protecting pills to the preparation of drugs for inhibiting proliferation of mouse lymphoma cells YAC-1.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Yulu Baofei Pills. Background technique [0002] Yulu Baofei Pills are recorded in the Ministry of Health Standard WS3-B-0238-90. The prescriptions are Asparagus 120g, Ophiopogon 120g, Dendrobium 80g, Rehmannia glutinosa 80g, Rehmannia glutinosa 80g, Anemarrhena 40g, Phellodendron amurense 40g, the above seven flavors, crushed into fine The powder is sieved and mixed. For every 100g of powder, 70-90g of refined honey is added to make a big honey pill. It can nourish yin and clear away heat, moisten lungs and stop coughing. It is used for coughing with yin deficiency, dumb voice, thirst, dry throat, and blood in sputum. [0003] In the prior art, there has not been a report on the use of supercritical technology in the extraction and preparation of Yulu Baofei Pills. However, the method of powdering is used, the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K9/20A61P35/00
Inventor 李健曹广超王丽君李军郭仲平
Owner 山东一言本草生物科技有限公司
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