Method for evaluating immunization effect of vaccine used in breeder birds and egg birds based on egg laying protection index

An evaluation method and technology of immune effect, applied in the field of preventive veterinary medicine, can solve problems such as quantitative evaluation of discomfort, and achieve the effect of quick evaluation and accurate evaluation method

Inactive Publication Date: 2014-04-30
INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
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  • Application Information

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Problems solved by technology

However, because the above pathogens only cause a decrease in egg production rate of breeding (egg) poultry without killing the breeding (egg) poultry or the lethality rate is very low, the original evaluation method is not suitable for the quantitative evaluation of the corresponding vaccine immunity effect of these diseases. , we take the egg production rate of breeding (egg) poultry as the assessment object, and establish the "egg production protection index" "Evaluation system provides a scientific and effective method for the quantitative evaluation of the immune effect of vaccines for breeding (egg) poultry in my country.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Derivation of Calculation Formula of Egg Production Protection Index

[0015] The egg production protection index calculation formula of the present invention is deduced and obtained by the following method:

[0016] 1. Concept

[0017] 1.1 Protection index

[0018] The protection index usually refers to the ability of drugs or vaccines to protect the host against pathogenic microorganisms. It is usually used to evaluate the effect of drugs or vaccines prepared from pathogens that can cause animal disease (or death) to protect animals against pathogenic microorganisms. In terms of biological vaccines, its The calculation formula is:

[0019] Protection index (PI) = (mortality rate of the challenge group - fatality rate of the immune challenge group) / case fatality rate of the challenge group × 100%

[0020] 1.2 Egg production protection index

[0021] After the breeding (egg) poultry is infected by pathogens such as avian Tembusu virus or egg-laying syndrom...

Embodiment 2

[0047] Taking the poultry Tembusu virus inactivated vaccine as an example, the implementation of the vaccine immune effect evaluation system based on egg production protection index is described in detail:

[0048] The pathogen used for the challenge is poultry Tembusu virus, and the vaccine is an oil emulsion inactivated vaccine emulsified with an adjuvant after the virus is inactivated.

[0049] 90 160-day-old healthy shelduck ducks (both of which were negative for poultry Tembusu virus and its antibodies) were used as experimental animal models. The egg production rate of group B was similar), and the egg-laying ducklings of group B were immunized with the prepared poultry tambushu virus oil emulsion inactivated vaccine through the leg muscles, with a single dose of 1ml per duck, and groups A and C were vaccinated through the leg muscles. Intramuscularly inject 1 mL of oil emulsion prepared with physiological saline as the aqueous phase into the legs. On the 28th day after...

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Abstract

The invention relates to a method for evaluating immunization effect of vaccine used in breeder birds and egg birds (breeder (egg) birds for short) based on egg laying protection index, belonging to the field of preventive veterinary medicine. According to the method, the laying rates of breeder (egg) birds are set as an examination object, and the immunization performance index of bird vaccines in protecting breeder birds and egg birds from resisting pathogenic microorganism hazards and keeping good egg laying performance is evaluated by comparing the laying rate difference of vaccine immunized breeder (egg) birds and non-immunized breeder (egg) birds after being attacked by the corresponding pathogenic microorganisms. The evaluation method established by the invention is simple, accurate and scientific, is not only used for visual and scientific evaluation of the immunization effect of a vaccine with egg laying performance as index, but also used for determination of the virulence of a pathogenic microorganism which does not cause death of breeder birds (egg) birds but has an impact on the egg laying performance, so as to overcome the difficulty in method for virulence test, vaccine immunogenicity determination and vaccine immunization effect quantitative evaluation. The method of the invention fills the gap in China and abroad.

Description

technical field [0001] The invention relates to a method for evaluating the immune effect of a vaccine for breeding (egg) poultry based on an egg-laying protection index (Egg-laying protection index, EPI), which belongs to the field of preventive veterinary medicine. Background technique [0002] In recent years, the problem of abnormal egg production caused by epidemic diseases in my country's breeding poultry and laying poultry has become more and more serious. Economic losses. Existing studies have shown that many pathogens can lead to the decline of egg production in breeding (egg) poultry, such as chicken egg drop syndrome virus, H9 subtype avian influenza virus, avian Tembusu virus, etc. [0003] In my country, vaccination is the most effective prevention and control measure against animal diseases, but the evaluation of its immune effect is limited to the morbidity and mortality of immunized livestock and poultry. However, because the above pathogens only cause a dro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 黄瑜傅光华万春和施少华程龙飞傅秋玲陈红梅林建生
Owner INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
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