Automatic Reconstitution Device for Dual Chamber Syringes

Abstract

An automatic mixing device, an actuation device removably mountable to the automatic mixing device, and a retractable syringe having the automatic mixing device are provided. The actuation device has an initial compression spring and a trigger member that initiates decompression of the spring to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is axially movable upon depression of the mixing plunger from a first position in sealing engagement with the one or more apertures in the inner barrel to intermediate the aperture or vent holes in the outer barrel the second position of . This allows depression of the mixing plunger to force the first substance from the outer chamber through the aperture to mix with the second substance in the inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe by subsequent needle retraction.

Description

technical field [0001] The present invention relates to mixing devices for syringes. More particularly, the present invention relates to automatic mixing devices of retractable syringes capable of storing, mixing and injecting one or more pharmaceutical substances. Background technique [0002] It is known to provide syringes comprising mixing devices for mixing deliverable substances prior to injection. This allows, for example, the addition of diluents to dehydrated, lyophilized, dried or powdered active substances immediately prior to injection, which is particularly useful for substances that are subject to deterioration or loss of activity when stored in hydrated form. [0003] Most mixing devices for syringes utilize a continuous chamber, where the syringe has a barrel with a first proximal chamber and a second distal chamber separated by, for example, a membrane or elastomeric seal. Many of these continuous lumen mixing syringes utilize bypass protrusions at the cro...

AI Technical Summary

Problems solved by technology

This venting requirement can create difficulties and require additional equipment and processing steps, such as requiring the lumen to be filled under vacuum to remove all air from the lumen and the distal portion of the outer barrel beneath the second reconstitution seal

[0007] Typically, prior art mixing devices comprising concentric cylinders are structurally complex and often require rotating the cylinders to align the one or more small holes that allow the liquid substance to flow from one chamber to the other

In addition to this, the various arrangements of sterility, sealing and venting that have been used present severe limitations in terms of ease of manufacture and handling of mixing devices

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