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A kind of nanopesticide composition and preparation method thereof

A technology for nano-pesticide and composition, which is applied in the fields of botanical equipment and methods, nanotechnology, nanotechnology, etc., to achieve the effects of simple and easy preparation method, good lasting effect, and good control effect.

Active Publication Date: 2015-11-04
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no technology to solve the compounding problem of hydrophilic pesticides and hydrophobic pesticides in pesticide nanocapsules

Method used

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  • A kind of nanopesticide composition and preparation method thereof
  • A kind of nanopesticide composition and preparation method thereof
  • A kind of nanopesticide composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) 20 mg of amphiphilic polymer (polyethylene glycol monomethyl ether-polylactic acid-glycolic acid, mPEG-PLGA, purchased from Jinan Daigang Biotechnology Co., Ltd., the monopolyethylene glycol methyl ether-poly The hydrophilic group of the lactic acid-glycolic acid copolymer is a polyethylene glycol monomethyl ether group, and the hydrophobic group is a polylactic acid-glycolic acid group, and the polyethylene glycol monomethyl ether-polylactic acid-glycolic acid copolymerization The arrangement of the repeating units of the compound is block type, and the molecular weight is 2.5×10 4 ) and 2 mg of hydrophobic drug (hexaconazole) were dissolved in 1 mL of organic solvent (dichloromethane) to obtain the first solution; hydrophilic drug (Jinggangmycin) was dissolved in water to obtain a drug with a concentration of 40 mg / mL solution to obtain a second solution; add 200 μL of the second solution to the first solution, and use ultrasonic emulsification with a power of 3% ...

Embodiment 2

[0053] In this example, the nano-pesticide composition was prepared according to the same method as in Example 1, except that 20 mg of amphiphilic polymer (polyethylene glycol monomethyl ether-polylactic acid-glycolic acid, mPEG-PLGA, commercially available From Jinan Daigang Biotechnology Co., Ltd., the hydrophilic group of the polyethylene glycol monomethyl ether-polylactic acid-glycolic acid copolymer is polyethylene glycol monomethyl ether group, and the hydrophobic group is polylactic acid-glycolic acid group, the arrangement of the repeating units of the polyethylene glycol monomethyl ether-polylactic acid-glycolic acid copolymer is a block type, and the molecular weight is 4.5×10 4 ) and 2 mg of hydrophobic drug (hexaconazole) were dissolved in 1 ml of organic solvent (dichloromethane) to obtain the first solution.

[0054] According to the same measurement method as in Example 1, the particle diameter of the nano-pesticide composition obtained in this embodiment is 260...

Embodiment 3

[0056] In this example, the nanopesticide composition was prepared according to the same method as in Example 1, except that the amphiphilic polymer was poly-L-lactic acid.

[0057] According to the same measurement method as in Example 1, the particle diameter of the nano-pesticide composition obtained in this embodiment is 2980.3nm by using a laser particle size analyzer; Vegetarian 0.075 mg.

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Abstract

The invention relates to a nano pesticide composition and a preparation method of the nano pesticide composition. The preparation method comprises the following steps: (1), mixing a first solution and a second solution, and emulsifying to obtain a first emulsion, wherein the first solution contains an amphiphilic polymer, a hydrophobic pesticide and an organic solvent, and the second solution contains a hydrophilic pesticide and water; (2), mixing the first emulsion obtained in the step (1) and a third solution containing the emulsifying agent and the water, and emulsifying to obtain a second emulsion; and (3), removing the organic solvent in the second emulsion obtained in the step (2), and separating to obtain the nano pesticide composition. According to the nano pesticide composition, according to a principle of forming a nano micelle of oil in water and water in oil by the amphiphilic polymer through a two-emulsion method, the hydrophilic pesticide and the hydrophobic pesticide are respectively coated on different cell layers of a nano cell, and thus co-transferring and loading of the hydrophilic pesticide and the hydrophobic pesticide is realized. According to the nano pesticide composition, through a method which is simple, convenient and easy to operate, the problem of compounding of the hydrophilic pesticide and the hydrophobic pesticide in the nano pesticide is solved.

Description

technical field [0001] The invention relates to a pesticide composition and a preparation method thereof, in particular to a nanometer pesticide composition and a preparation method thereof. Background technique [0002] In recent years, in order to solve the problems of large amount of organic solvent and low effective utilization rate of pesticides in traditional pesticide formulations, research and development of new pesticide formulations with slow and controlled release, targeted deposition and environmental compatibility have become the development trend of pesticide formulation processing. . Pesticide sustained and controlled release system is one of the main new dosage forms at present, mainly including nanocapsules and microcapsules. Compared with microcapsules, nanocapsules have smaller particle size and better passive targeting; Permeability is better. [0003] One of the main choices for nanosized drug carriers is amphiphilic polymers, which have hydrophilic en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/653A01N25/26B82Y30/00A01P3/00A01N43/16
Inventor 吴雁张嘉坤黄啟良
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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