Unlock instant, AI-driven research and patent intelligence for your innovation.

Composition capable of eliminating tween-type surfactants from blurring

A surfactant and composition technology, applied in the field of pharmaceutical preparations, can solve the problems of manpower, material resources, financial resources loss, preparation scrapping, application prospect discounts, etc.

Inactive Publication Date: 2015-12-09
SHENYANG PHARMA UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] If it is in large-scale industrial production, the serious consequences that may be caused by the phenomenon of Tween surfactants are: when a batch or even several batches of injections that use Tween surfactants as solubilizers are sterilized, due to the This leads to the scrapping of preparations, which not only causes multiple unnecessary losses in manpower, material resources, and financial resources of the enterprise, but also leads to the uncontrollability of the process and the randomness of qualified preparations in the preparation process of sterilized preparations related to Tween surfactants.
[0010] In addition, Tween-like surfactants may also lead to serious consequences, such as greatly reducing their application prospects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Coenzyme Q solubilized with common Tween surfactants alone 10 Preparation of Injection

[0029]

Prescription 1 Prescription 2 Prescription 3 Prescription 4 Prescription 5 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg Tween-20 600mg

Tween-40

600mg

Tween-60

600mg

Tween-80

600mg

Tween-85

600mg Water for Injection 28 ml 28 ml 28 ml 28 ml 28 ml

[0030] Process:

[0031] Weigh the prescribed amount of coenzyme Q 10, Tween-20 / Tween-40 / Tween-60 / Tween-80 / Tween-85 / compose the oil phase; measure the prescribed amount of water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances in the oil phase are completely dissolved, under the condition of magnetic stirring, slowly add the water phase into the oil phase, continue to stir for 20 minutes, dilute to 30mL with wate...

Embodiment 2

[0034] Example 2: Coenzyme Q Solubilized with Tween-80 without Sudden Phenomenon 10 Preparation of injections (fix Tween-80:F68=1:2(m / m), choose different amounts of propylene glycol for polyols)

[0035] prescription:

[0036]

Prescription 6 Prescription 7 Prescription 8 Prescription 9 Prescription 10 Prescription 11 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg 75mg Tween-80 600mg 600mg 600mg 600mg 600mg 600mg F68 1200mg 1200mg 1200mg 1200mg 1200mg 1200mg Propylene Glycol 1800mg 2400mg 3000mg 3600mg 4800mg 6000mg Water for Injection Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml

[0037] Process:

[0038] Weigh the prescribed amount of coenzyme Q 10 , Tween-80 to form the oil phase; take the prescribed amount of F68, propylene glycol and water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances ...

Embodiment 3

[0042] Example 3: Coenzyme Q Solubilized with Tween-80 without Sudden Phenomenon 10 Preparation of injections (fix Tween-80:F68=1:3(m / m), polyols choose different amounts of glycerin)

[0043] prescription:

[0044]

Prescription 12 Prescription 13 Prescription 14 Prescription 15 Prescription 16 Prescription 17 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg 75mg Tween-80 600mg 600mg 600mg 600mg 600mg 600mg F68 1800mg 1800mg 1800mg 1800mg 1800mg 1800mg glycerin 1800mg 2400mg 3000mg 3600mg 4800mg 6000mg Water for Injection Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml

[0045] Process:

[0046] Weigh the prescribed amount of coenzyme Q 10 , Tween-80 to form the oil phase; take the prescribed amount of F68, glycerin and water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances in the two phases are co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a composition capable of eliminating the clouding phenomenon of Tween sufactants and application thereof in medicinal preparations. The composition comprises the following components in parts by weight: 0.001-2 parts of an insoluble medicine, 1 part of Tween surfactant, 0.5-5 parts of polyoxyethylene polyoxypropylene copolymer, 2-20 parts of polyhydroxy compound, and the balance of water. When used for preparing common insoluble medicinal injections, the composition can endure sterilization at 100 DEG C for 30 minutes, and 121 DEG C for 8 minutes, and the clouding phenomenon does not happen, so that the controllability of the whole preparation process is guaranteed, negative results caused by the clouding phenomenon when the preparation is sterilized can be avoided, and serious problems when the Tween surfactants are applied to industrial production can be solved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and discloses a combination capable of eliminating the phenomenon of Tween-like surfactants from blurring and its application in pharmaceutical preparations. Background technique [0002] Polyoxyethylene sorbitan fatty acid ester, or Tween, is a polyol-type nonionic surfactant with the following structural formula: [0003] Its series of products mainly include Tween 20 (TWEEN-20), Tween 21 (TWEEN-21), Tween 40 (TWEEN-40), Tween 60 (TWEEN-60), Tween 61 (TWEEN-61), Tween Wen 80 (TWEEN-80), Tween 81 (TWEEN-81), Tween 85 (TWEEN-85). [0004] This type of surfactant has strong hydrophilicity, high stability, and is not easily affected by strong electrolytes, acids, alkalis, and salts. It can be mixed with other types of surfactants and has good solubility in various solvents, so it is widely used In the field of pharmaceutical preparations, especially Tween 80 (TWEEN-80) and Tween 20 (T...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34
Inventor 邓意辉程晓波王春玲张婷付强
Owner SHENYANG PHARMA UNIVERSITY