Unlock instant, AI-driven research and patent intelligence for your innovation.

Composition capable of eliminating hs15 epilepsy and its application in pharmaceutical preparations

A technology of composition and phenomena, applied in the field of pharmaceutical preparations, can solve the problems of manpower, material resources, financial resources loss, application prospect discount, scrapping, etc.

Inactive Publication Date: 2015-12-09
SHENYANG PHARMA UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In the case of large-scale industrial production, the serious consequences that may be caused by the HS15 flash phenomenon are: the scrapping of a batch or even several consecutive batches of HS15-related preparations will not only cause multiple unnecessary losses in manpower, material resources, and financial resources of the enterprise, but also lead to HS15 The uncontrollability of the process in the preparation process of related preparations and the randomness of qualified preparations
[0014] In addition, the HS15 epidemiology may also lead to serious consequences that greatly reduce its application prospects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition capable of eliminating hs15 epilepsy and its application in pharmaceutical preparations
  • Composition capable of eliminating hs15 epilepsy and its application in pharmaceutical preparations
  • Composition capable of eliminating hs15 epilepsy and its application in pharmaceutical preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Coenzyme Q Solubilized with HS15 without Sudden Phenomenon 10 Preparation of injection (fix HS15:F68=1:2(m / m), choose different amount of propylene glycol for polyol)

[0035] prescription:

[0036]

Prescription 1 Prescription 2 Prescription 3 Prescription 4 Prescription 5 Prescription 6 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg 75mg HS15 600mg 600mg 600mg 600mg 600mg 600mg F68 1200mg 1200mg 1200mg 1200mg 1200mg 1200mg Propylene Glycol 1800mg 2400mg 3000mg 3600mg 4800mg 6000mg Water for Injection Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml

[0037] Process:

[0038] Weigh the prescribed amount of coenzyme Q 10 , HS15 to form the oil phase; take the prescribed amount of F68, propylene glycol and water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances in the two phases are ...

Embodiment 2

[0042] Example 2: Coenzyme Q Solubilized with HS15 without Sudden Phenomenon 10 Preparation of injections (fix HS15:F68=1:3(m / m), polyols choose different amounts of glycerol)

[0043] prescription:

[0044]

Prescription 7 Prescription 8 Prescription 9 Prescription 10 Prescription 11 Prescription 12 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg 75mg HS15 600mg 600mg 600mg 600mg 600mg 600mg F68 1800mg 1800mg 1800mg 1800mg 1800mg 1800mg glycerin 1800mg 2400mg 3000mg 3600mg 4800mg 6000mg Water for Injection Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml

[0045] Process:

[0046] Weigh the prescribed amount of coenzyme Q 10 , HS15 to form the oil phase; measure the prescribed amount of F68, glycerin and water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances in the two phases are completely dissolved...

Embodiment 3

[0050] Example 3: Coenzyme Q Solubilized with HS15 without Sudden Phenomenon 10 Preparation of injections (fix HS15:F68=1:4(m / m), choose different amounts of PEG400 for polyols)

[0051] prescription:

[0052]

Prescription 13 Prescription 14 Prescription 15 Prescription 16 Prescription 17 Prescription 18 coenzyme Q 10 75mg 75mg 75mg 75mg 75mg 75mg HS15 600mg 600mg 600mg 600mg 600mg 600mg F68 2400mg 2400mg 2400mg 2400mg 2400mg 2400mg PEG400 1800mg 2400mg 3000mg 3600mg 4800mg 6000mg Water for Injection Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml Add to 30ml

[0053] Process:

[0054] Weigh the prescribed amount of coenzyme Q 10 , HS15 to form the oil phase; measure the prescribed amount of F68, PEG400 and water for injection as the water phase, and heat the two phases to 55°C respectively. After the substances in the two phases are completely dissol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a composition capable of eliminating clouding formation phenomenon of HS15 (polyethylene 10% w / v glycol 660 hydroxy stearate), which comprises a lipid soluble drug, HS15, a polyethylene oxide-polypropylene oxide copolymer, a polyhydroxylated compound and water, wherein the weight ratio of insoluble drug to HS15 to polyethylene oxide-polypropylene oxide copolymer to the polyhydroxylated compound is (0.001-2):1:(0.5-5):(2-20), and the rest is water. When the composition is used for preparing injection of common insoluble drug, the obtained preparation can bear sterilization at 100DEG C for 30 min and 121DEG C for 8 min without clouding formation, so as to ensure the controllability of the entire preparation process and avoid negative results arising from clouding formation phenomenon during sterilization of the preparation. The composition disclosed by the invention eliminates the clouding formation phenomenon of HS15, and solves the serious problem when HS15 is applied to industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to a combination capable of eliminating HS15 epilepsy and its application in pharmaceutical preparations. Background technique [0002] Surfactant refers to a substance that has fixed hydrophilic and lipophilic groups, can be aligned on the surface of the solution, and can significantly reduce the surface tension. According to the dissociation properties of polar groups, they can be divided into anionic surfactants, cationic surfactants, zwitterionic surfactants, and nonionic surfactants. [0003] Among different types of surfactants, the application of nonionic surfactants in pharmacy is more prominent, especially polyoxyethylene nonionic surfactants, whose performance is superior to other types of surfactants in many aspects , It has high stability, is not affected by strong electrolytes, acids, alkalis, and salts, and has good compatibility with ot...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34
Inventor 邓意辉程晓波王春玲王宇付强
Owner SHENYANG PHARMA UNIVERSITY