Application of acteoside in preparing medicine protecting cranial nerve cells damaged by ingestion and restraint of glutamate transporter
A technology of acteoside and brain nerve cells, which is applied to the application field of acteoside in the preparation of drugs to protect brain nerves, and can solve the problems of protecting brain nerve cells that have not yet been seen
Inactive Publication Date: 2014-05-28
新疆维吾尔自治区维吾尔医药研究所
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Problems solved by technology
[0008]The above studies show that acteoside mainly protects the cranial nerves by inhibiting cholinesterase activity, anti-oxidation, inhibiting glutamic acid and anti-apoptosis , but so far, there is no research report that it protects brain nerve cells by acting on glutamate transporters
Method used
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Examples
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Effect test
Embodiment 1
[0023] Example 1: Application of acteosides in the preparation of a drug for protecting brain nerve cells from damage caused by inhibition of glutamate transporter uptake. The structural formula of acteoside like Figure 6 shown.
Embodiment 2
[0024] Embodiment 2: The difference from the above-mentioned examples is that the content of acteoside is 90% to 99.9%, based on the weight of dry product.
Embodiment 3
[0025] Embodiment 3: The difference from the above examples is that the acteoside is the acteoside extracted from plants or the acteoside obtained through synthesis.
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The invention relates to the technical field of application of acteoside in preparing medicines protecting cranial nerves, in particular to application of acteoside in preparing a medicine protecting cranial nerve cells damaged by ingestion and restraint of glutamate transporter. The application of the acteoside provides that the acteoside acts on the glutamate transporter to play function of protecting the cranial nerve cells for the first time; the acteoside can improve learning ability and memory remarkably, and improve SOD activity, EAAT2mRNA transcription level of nerve cells and expressing level of the EAAT2 gene of cranial nerve cells, so that the acteoside has a remarkable protective effect on the cranial nerve cells damaged by ingestion and restraint of the glutamate transporter; the protective mechanism relates to up regulation of expressing level of the EAAT2 gene; the application of acteoside has an important significance in seeking for a novel and effective medicine curing chronic neurodegenerative diseases.
Description
technical field [0001] The invention relates to the technical field of application of acteosides in the preparation of drugs for protecting cranial nerves, and relates to the application of acteosides in the preparation of drugs for protecting brain nerve cells damaged by glutamate transporter uptake inhibition. Background technique [0002] Glutamate is the most important excitatory neurotransmitter in the mammalian central nervous system (CNS), involved in synaptic transmission, and the signal transduction mediated by it constitutes the basis of memory and cognition, and it is an important neuron related to learning and memory. Transmitter. Brain tissue contains a large amount of glutamic acid. Under normal circumstances, most of it exists in the cell, and only a few exist in the intercellular space. The transmembrane concentration gradient is about several thousand times. Since there are no extracellular glutamate metabolizing enzymes, the only way to inactivate glutamat...
Claims
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Inventor 高莉彭晓明霍仕霞闫明
Owner 新疆维吾尔自治区维吾尔医药研究所
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