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A kind of lysozyme hydrochloride oral spray and preparation method thereof

A technology of lysozyme hydrochloride and oral spray, which is applied in anti-inflammatory agents, antibacterial drugs, antiviral agents, etc., and can solve problems such as reduced enzyme activity, instability of lysozyme hydrochloride, and poor curative effect

Active Publication Date: 2016-03-02
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the lysozyme hydrochloride in ordinary lysozyme hydrochloride buccal tablets is quite unstable, the granules need to be dried during the preparation process, and the enzyme activity is reduced to varying degrees; the curative effect is not good

Method used

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  • A kind of lysozyme hydrochloride oral spray and preparation method thereof
  • A kind of lysozyme hydrochloride oral spray and preparation method thereof
  • A kind of lysozyme hydrochloride oral spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1. The preparation of lysozyme hydrochloride oral spray

[0096] Lysozyme hydrochloride oral spray consists of raw and auxiliary materials, all in parts by weight:

[0097] A: 100 parts of lysozyme hydrochloride;

[0098] B: 20 ​​parts of white sugar, 10 parts of glycerin, 5 parts of hydroxypropyl methylcellulose, 6 parts of glycine, 900 parts of water for injection;

[0099] Preparation:

[0100] (1) Weigh lysozyme hydrochloride, sugar, glycerin, hydroxypropyl methylcellulose, glycine and water for injection for later use;

[0101] (2) Add the weighed white sugar, glycerin and water for injection into the No. 1 dissolution tank, start stirring, heat up to 40°C, and make it completely dissolved before use;

[0102] (3) Add the weighed hydroxypropyl methylcellulose and water for injection into the No. 2 dissolution tank, stir well, and heat up to 70°C to completely dissolve it for later use;

[0103] (4) Pump the solution in No. 2 dissolving tank in step (...

Embodiment 2

[0106] Embodiment 2. The preparation of lysozyme hydrochloride oral spray

[0107] Lysozyme hydrochloride oral spray consists of raw and auxiliary materials, all in parts by weight:

[0108] A: 160 parts of lysozyme hydrochloride;

[0109] B: 26 parts of white sugar, 13 parts of glycerin, 7 parts of hydroxypropyl methylcellulose, 8 parts of glycine, 1440 parts of water for injection;

[0110] Preparation:

[0111] (1) Weigh lysozyme hydrochloride, sugar, glycerin, hydroxypropyl methylcellulose, glycine and water for injection for later use;

[0112] (2) Add the weighed white sugar, glycerin and water for injection into the No. 1 dissolution tank, start stirring, heat up to 60°C, and make it completely dissolved before use;

[0113] (3) Add the weighed hydroxypropyl methylcellulose and water for injection into the No. 2 dissolution tank, stir well, and heat up to 90°C to completely dissolve it for later use;

[0114] (4) Pump the solution in No. 2 dissolving tank in step (3...

Embodiment 3

[0117] Embodiment 3. The preparation of lysozyme hydrochloride oral spray

[0118] Lysozyme hydrochloride oral spray consists of raw and auxiliary materials, all in parts by weight:

[0119] A: 130 parts of lysozyme hydrochloride;

[0120] B: 23 parts of white sugar, 11 parts of glycerin, 6 parts of hydroxypropyl methylcellulose, 7 parts of glycine, 1170 parts of water for injection;

[0121] Preparation:

[0122] (1) Weigh lysozyme hydrochloride, sugar, glycerin, hydroxypropyl methylcellulose, glycine and water for injection for later use;

[0123] (2) Add the weighed sugar, glycerin and water for injection into the No. 1 dissolution tank, start stirring, heat up to 50°C, and make it completely dissolved before use;

[0124] (3) Add the weighed hydroxypropyl methylcellulose and water for injection into the No. 2 dissolution tank, stir well, and heat up to 80°C to completely dissolve it for later use;

[0125] (4) Pump the solution in No. 2 dissolving tank in step (3) into...

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Abstract

The invention discloses a lysozyme hydrochloride oral spray and a preparation method thereof. Active pharmaceutical components of the lysozyme hydrochloride oral spray include lysozyme hydrochloride and pharmaceutical auxiliary materials and comprise the following components: the lysozyme hydrochloride, white sugar, glycerol, hydroxypropyl methylcellulose, glycine and water for injection. The dosage form of the lysozyme hydrochloride oral spray is an oral spray; the lysozyme hydrochloride oral spray disclosed by the invention has the effects of antisepsis, anti-virus, hemostasis, detumescence, acesodyne and chronic faucitis and oral ulcer treatment by permeating the lysozyme hydrochloride into an oral ulcer sensitive tissue through an oral cavity.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a lysozyme hydrochloride oral spray for treating acute and chronic pharyngitis and oral ulcers and a preparation method thereof. Background technique [0002] Pharyngitis can be divided into acute pharyngitis and chronic pharyngitis. Acute pharyngitis is an acute inflammation of the pharyngeal mucosa and submucosal tissues. Pharyngeal lymphoid tissue is often involved. Inflammation can be localized in the early stage, and can often involve the entire pharyngeal cavity as the disease progresses, and it is more common in autumn and winter and winter and spring. Chronic pharyngitis, also known as chronic simple pharyngitis, is more common. Lesions are mainly in the mucosal layer, manifested as chronic congestion of the pharyngeal mucosa. Hyperplasia of mucosa and submucosal connective tissue. Mucous glands can be hypertrophic, hypersecretory, and mucus secre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K38/47A61P1/02A61P31/04A61P11/04A61P31/12A61P29/00
Inventor 乔敏袁武杰刘钢李红新孟震晓邵兰兰
Owner SHANDONG SBOND PHARMA
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