Piroxicam tablets and preparation process thereof

A kind of technology of piroxicam tablet and preparation process, applied in the field of piroxicam tablet and its preparation, can solve the problems such as unsatisfactory curative effect

Inactive Publication Date: 2014-06-18
崔书豪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Existing drugs for the treatment of rheumatoid arthritis and painful oste...

Method used

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  • Piroxicam tablets and preparation process thereof
  • Piroxicam tablets and preparation process thereof
  • Piroxicam tablets and preparation process thereof

Examples

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Embodiment Construction

[0017] The present invention is further explained below in conjunction with the examples, but the examples do not limit the present invention in any form.

[0018] (1) Making tablet cores: pass piroxicam, lactose, pregelatinized starch, hydroxypropyl methylcellulose, and sodium starch glycolate through a 100-mesh sieve, and add them into the wet mixing granulator according to the method of equal increments and mix evenly , to obtain mixed powder; dissolve polysorbate-80 in 30-50 times of ethanol, add to the above mixed powder, mix, and then add 15% pregelatinized starch for pulping to the mixed powder to make 18 ~40-mesh granules, dried at 60-70°C, sieved with 24-mesh sieve, collected when the water content is 1.0-3.0%, and prepared tablet cores for later use;

[0019] (2) Coating: the stomach-soluble film coating premix is ​​formulated with 80% ethanol into a 11% suspension, stirred and mixed for 60 minutes for later use; the tablet cores are poured into the coating pot, and ...

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PUM

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Abstract

The invention discloses piroxicam tablets and a preparation process and purposes thereof. The product consists of piroxicam, lactose, pregelatinized starch, hydroxypropyl methyl cellulose, carboxymethyl starch sodium, polysorbate-80, 15% pregelatinized starch for slushing, superfine silica powder, magnesium stearate and a gastric soluble film coating premix. The production method comprises the steps: preparing tablet cores, coating and the like. The piroxicam tablets are used for treating 30 cases of rheumatoid arthritis, have good curative effects of diminishing inflammation and relieving pain and have slight influence on erythrocyte sedimentation rate, the total effective rate is 88 percent, and the piroxicam tablets have the characteristics of low administration frequency, stable blood concentration, long duration and the like.

Description

field of invention [0001] The invention relates to the field of chemical pharmacy, in particular to a piroxicam tablet and a preparation process thereof. Background of the invention [0002] Arthritis is a common and chronic disease, in which osteoarthritis and rheumatoid arthritis are the main forms. According to reports, about 18% of the people in our country suffer from some form of arthritis, and the number of cases exceeds 200 million. Arthritis is a serious threat to human health, affecting the life and work of patients, making some patients unable to take care of themselves and lose their ability to work. Some patients have restricted activities, joint swelling, stiffness and pain, and severe joint permanent deformation, which is an important cause of disability in the elderly, so timely treatment is required. [0003] Piroxicam (Piroxicam), also known as Pyroxicam, Pyroxythiazine, Anerke, Xipukang, Feidine, the chemical name is 2-methyl-4-hydroxy-N-(2-pyridyl)- 2H...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/5415A61P29/00A61P19/02
Inventor 崔书豪王志刚薛清佩陈洪瑜
Owner 崔书豪
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