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Use of lentinan as antidepressant drug

A technology for lentinan and anti-depression, which is applied in the field of medicine to achieve the effect of ensuring reliability

Inactive Publication Date: 2014-06-18
BEIJING GRAGEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-inflammatory, antibacterial, antiviral, and antitumor effects of lentinan have been confirmed by more and more clinical and basic experiments. However, there are no reports of scholars mentioning the compound lentinan for the treatment of depression.

Method used

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  • Use of lentinan as antidepressant drug
  • Use of lentinan as antidepressant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Effect of lentinan on tail suspension test of animal depression model.

[0038] Animal CD1 mouse, male, weighing 25-35 grams, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. Animals were housed in separate cages with free access to water, and the feed was provided by the Experimental Animal Center of the Institute of Genetics, Chinese Academy of Sciences. The common feed that the experimental mice could eat was acceptable.

[0039] Test drug:

[0040] Lentinan was purchased from Shanghai Fusheng Industrial Co., Ltd.

[0041] The positive control imipramine hydrochloride (Imipramine hydrochloride) is a product of Sigma Company, product number I7379, lot number O56K1380.

[0042] experiment equipment:

[0043] Cross bar, tape, Samsung Intelli-200m digital video camera (Samsung Corporation of South Korea), JUNSO multifunctional timer.

[0044] Experimental steps:

[0045] After adaptive fee...

Embodiment 2

[0057] Embodiment 2 mouse forced swimming experiment

[0058] Animals were male CD1 mice, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. One week before the experiment, the animals were reared in separate cages, the light and dark cycle was 12h / 12h, the room temperature was 20-22°C, and they were free to eat and drink. The feed was provided by the Experimental Animal Center of the Institute of Genetics, Chinese Academy of Sciences.

[0059] Experimental drug:

[0060] Lentinan (cordycepin), imipramine hydrochloride (Imipramine hydrochloride) are the same as embodiment 1. Test apparatus:

[0061] Glass cylinder (height 20cm, diameter 14cm); mouse open box (diameter 30cm, height 20cm, bottom 16 equal parts); thermometer; JUNSO multifunctional timer.

[0062] Drug preparation is the same as tail suspension experiment.

[0063] Lentinan mother solution: Lentinan dissolved in physiological saline 100mg / ml. ...

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Abstract

The invention discloses use of lentinan as an antidepressant drug, belongs to the field of medicine, and is characterized in that the lentinan or a lentinan derivative is used as an active component to prepare the antidepressant drug; the lentinan derivative is a glycoside prepared from the lentinan and a pharmaceutically acceptable salt, ester or sugar thereof; the antidepressant drug is used for the treatment or prevention of depression, has the advantages of significant anti-depression effect, quick effect, less side effect and the like, and is therefore an excellent anti-depression drug candidate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a rapid antidepressant drug mainly composed of lentinan. Background technique [0002] Depression has become a common and frequently-occurring disease in modern society, and its incidence is still increasing. Symptoms are characterized by depressed mood, loss of interest, slow thinking, and decreased speech and actions. Severe depression has world-weary or suicidal thoughts. The suffering caused by such diseases to patients and their families, as well as the loss to society, are unmatched by many other diseases. According to the report published by the World Health Organization (WHO), affective disorder has become the fourth largest disease in the world, and the number of depressed patients in the world has reached 340 million. The current incidence of depression in China is about 4%. At least 26 million people in China suffer from depression, and the total economic burden caused by de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P25/24
Inventor 杜静
Owner BEIJING GRAGEN BIOTECH
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