Method for identifying natural musk and muskone

A technology of artificial musk and natural musk, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of long separation time, long processing time, high toxicity, etc., and achieve the effects of low fluid viscosity, short running time and low cost

Active Publication Date: 2014-06-18
BEIJING UNIV OF CHINESE MEDICINE +1
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Problems solved by technology

[0005] Liang Ying and Wang Xiaogen (preliminary analysis of natural musk and artificial musk by GC-MS method, "New Drugs and Clinical Pharmacology of Traditional Chinese Medicine", 2005, Volume 16, No. 3, p204-205) reported that musk pyridine, 3-methylcyclo Tridecone is used as a specific ingredient, and the GC-MS method is used to identify natural musk and artificial musk. This method can accurately identify natural musk and artificial musk, but there are the following deficiencies: the extraction reagent uses benzene, which is highly toxic; the pretreatment time of the test product Long, more than 1.5h; long separation time, the retention time of specific components is more ...

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  • Method for identifying natural musk and muskone
  • Method for identifying natural musk and muskone
  • Method for identifying natural musk and muskone

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Embodiment 1

[0050] The identification method of embodiment 1 natural musk and artificial musk

[0051] 1. Preparation of mixed reference solution:

[0052] Precisely weigh 0.5 mg of the reference substance of hexacanoic acid and 0.5 mg of the reference substance of octacosanoic acid, put them in a 50 mL volumetric flask, add n-hexane solvent to dissolve, and constant volume to obtain the product.

[0053] 2. Preparation of the test solution:

[0054] Accurately weigh about 0.05 g of the musk sample to be tested, place it in a conical flask, add 10 mL of ethyl acetate, ultrasonicate for 10 min, and filter to obtain the product.

[0055] 3. Test method:

[0056] Take the mixed reference substance solution and the test solution respectively, inject them into the ultra-high performance convergence chromatography tandem mass spectrometer, and obtain the total ion chromatogram of the reference solution and the total ion of the test solution according to the following ultra-high performance co...

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Abstract

The invention discloses a method for identifying natural musk and muskone. The method comprises the following step: with hexacosanoic acid and octacosanoic acid as reference substances, performing qualitative identification by adopting an ultrahigh performance bonded-phase chromatography-tandem mass spectrometry method. The method disclosed by the invention is used for identifying the natural musk and the muskone; a sample is simple in pretreatment, and rapid, accurate, and environmentally friendly in detection.

Description

technical field [0001] The invention belongs to the field of drug analysis, in particular to a method for identifying natural musk and artificial musk. Background technique [0002] Natural musk (Moschus) is a precious and rare Chinese medicinal material. It is the dry secretion in the mature male sachet of the deer animal Moschus berezovskii Flerov, Moschus sifanicus Przewalski or the original musk deer Moschus moschiferus Linnaeus. The musk deer is a first-class protected wild animal in the country. The source and output of natural musk are very limited, and most of the current clinical use is artificial musk. [0003] Artificial musk is a national first-class new drug developed according to the chemical components of natural musk. The types and contents of its chemical components are very similar to those of natural musk. . Compared with artificial musk, natural musk also contains many unknown trace components, and some of these trace components themselves have biologic...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/88
Inventor 马群解素花乔延江顾海鸥杜菁刘永刚
Owner BEIJING UNIV OF CHINESE MEDICINE
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