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Application of eight-treasure particle in preparation of drugs used for treating brain glioma

A technology based on Bazhen Granules and brain glioma, applied in the field of medicine, can solve problems such as lack of treatment methods, many complications, and difficult surgical resection, etc., and achieve the effect of inhibiting tumor growth, high malignancy, and strong invasiveness

Inactive Publication Date: 2014-06-25
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Glioma is one of the most common clinical intracranial malignant tumors, also known as glioma, which originated from neuroepithelial cells, and its incidence rate is 5-8/100,000 people. Due to the malignant infiltration of glioma Not only is it difficult to completely remove the operation, but also it is easy to relapse after surgery. For a long time, the 5-year survival rate of malignant glioma treated by surgery alone is less than 25%. Reasonable postoperativ

Method used

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Experimental program
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Effect test

Embodiment 1 8

[0010] The preparation of embodiment 1 Bazhen sample

[0011] Prescription: Codonopsis 60g, Baishao (fried) 60g, Atractylodes macrocephala (fried) 60g, Rehmannia glutinosa 90g, Poria cocos 60g, angelica 90g, Chuanxiong 45g, licorice (burned) 30g;

[0012] Preparation method: the above eight flavors, angelica, chuanxiong, and atractylodes rhizome are heated and refluxed with 95% ethanol and 50% ethanol once each, for 2 hours each time, filtered, the filtrates are combined, the ethanol is recovered, filtered, and the filtrate is used for later use; the dregs of the medicine and the rest of Codonopsis pilosula Wait for the five flavors to add water and decoct twice, each time for 1.5 hours, filter, combine the filtrates, add the above reserve liquid, concentrate into a thick paste, dilute with distilled water and set aside.

Embodiment 2

[0014] Rat C6 glioma cells were resuscitated, and RPMI-1640 medium containing 10% inactivated fetal bovine serum (containing NaHCO 3 2g / L, penicillin 100U / mL, streptomycin 100U / mL), put the culture bottle in 5% CO 2 , cultured in a constant temperature airtight cell incubator at 37°C, take 10 μL of C6 cells in the logarithmic growth phase, count them under the light microscope with a red blood cell counting plate, adjust the concentration so that each 10 μL contains 1×10 6 Then add 0.4% trypan blue isotonic saline solution at a ratio of 1:9, and confirm the survival rate of C6 glioma cells > 95% within 1 min.

[0015] Forty-six male SD rats aged 7 weeks were intraperitoneally anesthetized with chloral hydrate. The head of the rat brain stereotaxic instrument was fixed, and the ear needles were inserted deep into the external auditory canal. Cut the scalp, expose the skull layer by layer, and determine the position of bregma. 1mm in front of the midpoint of the bregma, 3.0-3...

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Abstract

The invention discloses novel application of an eight-treasure particle in preparation of drugs used for treating brain glioma. According to the invention, a large dose of eight-treasure thick paste is orally administrated, so tumor growth in mice with brain glioma is effectively inhibited, and apoptosis of glioma cells is substantially induced.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the use of Bazhen Granules in the preparation of medicines for treating brain gliomas. Background technique [0002] The composition of Bazhen Decoction, an ancient traditional Chinese medicine prescription, is 10g of angelica (mixed with wine), 5g of Chuanxiong, 8g of white peony, 15g of rehmannia glutinosa (mixed with wine), 3g of ginseng, 10g of Atractylodes macrocephala (stir-fried), 8g of poria cocos, 5g of roasted licorice; Cup, add three slices of ginger, two jujubes, fry until eight minutes, take it before eating. Bazhen Decoction is mainly used for the treatment of qi and blood deficiency syndrome, and is used for pale or sallow complexion, dizziness, fatigue of limbs, shortness of breath, indolence to speak, palpitation, reduced diet, pale tongue with thin white coating, weak or weak pulse. The main compatibility characteristics of Bazhen Decoction are: tonify qi and...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P35/00
Inventor 王学政鲁俞江尤斌林爱弟陈旦凤陈胜胜孙卓亚朱德振
Owner NINGBO LIWAH PHARM CO LTD
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