Application of circRAPGEF51 to pituitary adenoma biomarkers

A pituitary adenoma and biomarker technology, applied in the field of natural ribonucleotides, can solve the problems of poor tumor curative effect, high recurrence rate, fast growth of tumor residual tissue, etc., and achieve the effect of institutional stability

Inactive Publication Date: 2018-04-20
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Invasive growth makes it difficult to completely remove the tumor by surgery, and the commonly used drugs bromocriptine and somatostatin have poor curative effects on this type of tumor; invasive growth also limits its sensitivity to radiotherapy, and radiotherapy in the sellar region is easy Damage to important structures such as the normal pituitary gland, hypothalamus, and optic nerve
These factors lead to high postoperative recurrence rate and rapid growth of tumor residual tissue in aggressive pituitary adenomas

Method used

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  • Application of circRAPGEF51 to pituitary adenoma biomarkers
  • Application of circRAPGEF51 to pituitary adenoma biomarkers
  • Application of circRAPGEF51 to pituitary adenoma biomarkers

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Embodiment Construction

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention. The present invention will be further described below in conjunction with specific embodiment

[0020] 1. Experimental materials, clinical samples: clinical samples: tissue samples of 19 cases of pituitary adenoma (8 cases of invasive pituitary adenoma, 9 cases of non-invasive pituitary adenoma) were provided by the Second Affiliated Hospital of Dalian Medical University.

[0021] Reagents: circRNA-RAPGEF5-1 screening primers were synthesized by Invitrogen;

[...

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Abstract

The invention discloses application of circRAPGEF51 (circRNA-RAPGEF5-1) to pituitary adenoma biomarkers, and particularly relates to the technical field of purposes of natural ribonucleotide. The length of the circRNA-RAPGEF5-1 is 449bp; the circRNA-RAPGEF5-1 is positioned on 22347957 to 22357656 on a 7th chromosome of a human body; RAPGEF5 is a covering gene of the circRNA; the quantity of the circRNA-RAPGEF5-1 from a pituitary adenoma tissue sample of an object is detected; the lower-quantity circRNA-RAPGEF5-1 has high pituitary adenoma invasiveness and is relevant to the bad prognosis possibility increase of the object. The purpose of the circRNA-RAPGEF5-1 is provided. The circRNA-RAPGEF5-1 has the application prospects of becoming the pituitary adenoma biomarkers.

Description

technical field [0001] The present invention relates to the application of circRAPGEF51 (circRNA-RAPGEF5-1) in pituitary adenoma biomarkers, specifically the technical field of application of natural ribonucleotides. Background technique [0002] Pituitary adenoma (pituitary tumor for short) is one of the most common intracranial tumors in humans, accounting for about 10%-15% of intracranial tumors. Pituitary tumors are benign tumors histologically, but some pituitary tumors grow aggressively, enveloping or invading the surrounding tissue structure, and it is difficult to completely remove this part of the tumor, which is one of the main reasons for tumor recurrence. According to the biological behavior of pituitary tumors, they can be divided into non-invasive pituitary tumors, invasive pituitary tumors and pituitary carcinomas. Invasive pituitary tumors are between non-invasive pituitary tumors and pituitary carcinomas. Their histological appearance is benign, but their b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 张波王翔娄佳成李欣宇吕逸竹郝宇超
Owner THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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