Chinese herbal compound composition with blood fat reduction effect, and applications thereof

A composition and blood lipid-lowering technology, which are applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as adverse reactions, and achieve good curative effects, scientific and reasonable proportions, and prevention and treatment of atherosclerosis. Effect

Active Publication Date: 2014-06-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, Chinese and Western lipid-lowering drugs include statins and fibrates, which have certain clinical curative effects, but all have adverse reactions or contraindications

Method used

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  • Chinese herbal compound composition with blood fat reduction effect, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1, a kind of Chinese medicine compound composition with hypolipidemic effect, it is made of the raw material of following parts by weight:

[0028] 0.5 parts of Ginkgo biloba extract, 45 parts of lotus leaf, 3 parts of Eucommia leaves, 3 parts of purslane, 45 parts of Gynostemma pentaphyllum, 50 parts of hawthorn, 45 parts of turmeric, 15 parts of jujube seed.

[0029] The Ginkgo biloba extract is prepared by the following method: Ginkgo biloba is properly crushed, 8 times the amount of 70% ethanol is added to reflux and extracted 3 times, each time for 1.5 hours, the extracts are combined, filtered, and the ethanol is recovered under reduced pressure. Add an appropriate amount of water-soluble powder, let it stand, filter, put it on the AB-8 resin column for adsorption, wash and clarify with water, elute with 95% ethanol, collect the eluate, concentrate under reduced pressure, put it on the polyamide column, wash with water first, and then use 70% ethanol to collect the...

Embodiment 2

[0032] 1, a kind of Chinese medicine compound composition with hypolipidemic effect, it is made of the raw material of following parts by weight:

[0033] 1 part of Ginkgo biloba extract, 90 parts of lotus leaf, 6 parts of Eucommia leaf, 6 parts of purslane, 90 parts of Gynostemma pentaphyllum, 100 parts of hawthorn, 90 parts of turmeric, 30 parts of wild jujube seed.

[0034] The Ginkgo biloba extract is prepared by the following method: Ginkgo biloba is properly crushed, 12 times the amount of 70% ethanol is added to reflux for extraction twice, each time for 1.5 hours, the extracts are combined, filtered, and the ethanol is recovered under reduced pressure. Add an appropriate amount of water-soluble powder, let it stand, filter, apply to D-101 resin column for adsorption, wash and clarify with water, and elute with 95% ethanol. % methanol for elution, collect 70% methanol eluate, concentrate under reduced pressure, and dry under reduced pressure.

[0035] 2. Take 90 parts ...

Embodiment 3

[0037] 1, a kind of Chinese medicine compound composition with hypolipidemic effect, it is made of the raw material of following parts by weight:

[0038] 2 parts of Ginkgo biloba extract, 180 parts of lotus leaf, 12 parts of Eucommia oleracea, 12 parts of purslane, 180 parts of Gynostemma pentaphyllum, 200 parts of hawthorn, 180 parts of turmeric, 60 parts of jujube seed.

[0039]The Ginkgo biloba extract is prepared by the following method: Ginkgo biloba is properly crushed, 10 times the amount of 70% ethanol is added to reflux for extraction once, each time for 1.5 hours, the extracts are combined, filtered, and the ethanol is recovered under reduced pressure. Add an appropriate amount of water-soluble powder, let it stand, filter, apply to D-101 resin column for adsorption, wash and clarify with water, and elute with 95% ethanol. % methanol for elution, collect 70% methanol eluate, concentrate under reduced pressure, and dry under reduced pressure.

[0040] 2. Take 180 pa...

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Abstract

The invention discloses a Chinese herbal compound composition with a blood fat reduction effect. The composition is prepared from the following active ingredients in parts by weight: 0.5-2 parts of ginkgo biloba extract, 45-180 parts of lotus leaves, 3-12 parts of eucommia ulmoides leaves, 3-12 parts of purslane, 45-180 parts of gynostemma pentaphyllum, 50-200 parts of hawthorn, 45-180 parts of radix curcuma, and 15-60 parts of semen ziziphi spinosae. Under the guidance of the theory of Chinese medicine, the formula is screened by adopting diagnosis and treatment based on an overall analysis through combining the pathogenesis and the symptoms of hyperlipemia, and the overall composition is scientific and reasonable in proportion. Experimental results show that the Chinese herbal compound composition has a good blood fat reduction effect and can prevent atherosclerosis and cardiovascular diseases; moreover, all herbal medicines in the composition are both medical and edible, thus being good in curative effect, low in toxic and side effects, and safer for clinical medication.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine compound composition with blood lipid-lowering effect and application thereof. Background technique [0002] Hyperlipidemia is mainly caused by the increase of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and the decrease of high-density lipoprotein cholesterol (HDL-C). It is also a major indicator of coronary artery disease and atherosclerosis. The treatment of hyperlipidemia includes diet control, exercise and drug therapy. Traditional Chinese and Western lipid-lowering drugs in the prior art include statins and fibrates, which have certain clinical curative effects, but all have adverse reactions or contraindications. [0003] Traditional Chinese medicine has a unique curative effect in the prevention and treatment of hyperlipidemia, and mainly because of its good clinical safety and small t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P3/06A61P9/10A61P9/00
Inventor 段金廒钱大玮郭建明郭盛宿树兰唐于平
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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