Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use

A technology for chronic kidney disease and renal function, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of high cost, low extraction rate of active ingredients, and complicated preparation process.

Active Publication Date: 2014-07-02
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the prior art discloses the combined use of rhubarb and astragalus to treat chronic kidney disease and chronic renal fai...

Method used

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  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use

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Experimental program
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Effect test

Embodiment 1

[0147](1) Take 600g of rhubarb and 1500g of salvia miltiorrhiza, crush them into coarse particles, add 8 times the amount of water to soak for 20 minutes, heat and ultrasonically extract for 20 minutes for the first time, filter; heat and ultrasonically extract for 10 minutes for the second time, filter, and combine two water extractions Liquid, concentrated under reduced pressure to a relative density of 1.21 at 60°C, added 5% gelatin solution to remove tannin, filtered, added ethanol to make the alcohol content 75%, stood still, filtered, took the filtrate and concentrated under reduced pressure to a relative density of 60 At 1.21 °C, recover ethanol, continue to add ethanol to make the alcohol content 80%, let stand, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, then add 0.3%-0.5% activated carbon, boil After 30 minutes, filter and adjust the pH value to 7.4-7.7 to obtain rhubarb and salvia miltiorrhiza extracts for later us...

Embodiment 2

[0151] (1) Take 600g of rhubarb and 1500g of salvia miltiorrhiza, crush them into coarse particles, add 8 times the amount of water to decoct, combine the extracts, filter, collect the filtrate, concentrate, enter the macroporous resin column for adsorption and separation, and collect the first effluent; first wash with water Remove, collect the eluate, and then elute with 50%-60% ethanol, collect the ethanol eluate, recover the ethanol until it has no alcohol smell, combine the effluent, concentrate under reduced pressure to a relative density of 1.21 at 60°C, add 5% Remove tannins from the gelatin solution, filter, add ethanol to make the alcohol content 75%, let stand, filter, take the filtrate and concentrate under reduced pressure to a relative density of 1.21 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content 80% , stand still, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, then add 0.3%-0.5% act...

Embodiment 3

[0155] (1) Take 600g of rhubarb and 1500g of salvia miltiorrhiza, crush them into fine particles and put them in the extraction kettle for CO 2 For supercritical extraction, the flow rate of the supercritical fluid entering the extraction kettle is 35L / h, the extraction pressure is 30MPa, the extraction temperature is 45°C, and the extraction time is 2.5h. The rhubarb and Danshen high-pressure fluids flowing out of the extraction kettle enter the separation kettle for Separation, separation pressure I is 8 Mpa, separation temperature I is 30°C; separation pressure II is 6 Mpa, separation temperature II is 25°C, collect the extracts of rhubarb and salvia miltiorrhiza, add water for injection to 2-3 times the amount of the liquid medicine , then add 0.3%-0.5% activated carbon, boil for 30min, filter, adjust the pH value to 7.4-7.7, and obtain rhubarb and salvia miltiorrhiza extracts, set aside;

[0156] (2) Take 2100g of Astragalus membranaceus and crush it into fine particles, ...

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Abstract

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the following raw material medicines by weight: 6-40 parts of rheum officinale, 10-95 parts of astragalus and 5-65 parts of salvia miltiorrhiza by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicine for treating chronic kidney disease and chronic renal failure and a preparation method thereof. Specifically, it belongs to the field of medicine. Background technique [0002] Chronic Kidney Disease (CKD) clinically includes chronic glomerulonephritis, nephrotic syndrome, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy and various secondary nephropathy, etc. The prevalence of vascular diseases is high and the mortality rate is high. In addition, the awareness rate of chronic kidney disease is low, the prevention rate is low, and the awareness rate of cardiovascular disease is low. It has become a global public health problem. Diagnosis of CKD is mainly based on two aspects: (1) kidney damage (displaying renal structural and functional abnormalities) for ≥ 3 months, with or without decreased glomerular filtration rate (GRF); (2) rena...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/19A61P13/12
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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