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Application of Hedyotis diffusa

A technology of Hedyotis diffusa and subarachnoid space, applied in the field of medicine, can solve the problems of unsatisfactory prognosis and high death and disability rate, and achieve the effect of improving neurological function scores, reducing the degree of spasm, and reducing the degree of damage

Active Publication Date: 2015-11-04
GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the prognosis of this disease is still unsatisfactory, with a mortality rate as high as 45%.

Method used

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  • Application of Hedyotis diffusa
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  • Application of Hedyotis diffusa

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1. The making of subarachnoid hemorrhage rat model

[0038]We established a SAH model in rats by means of internal carotid artery puncture according to the literature of Bederson et al. condition), adult healthy Sprague-Dawley (SD) rats with a body weight of 250-300 g were anesthetized with 10% chloral hydrate (3.5ml / kg) intraperitoneally and then fixed in supine position. Fix the head and limbs, prepare the skin and disinfect the front of the neck, take a median neck incision, and bluntly dissect to expose the right common carotid artery (CCA), external carotid artery (ECA) and internal carotid artery (internal carotid artery, ICA) ligation cuts off the anastomotic branch between the ECA and the ICA, ligates the ECA and cuts it straight so that it is in line with the ICA. Take a 3-0 single-strand nylon thread (diameter 0.261mm) to sharpen the head end, mark the 20mm and 22mm at the end of the thread, and insert the nylon thread from the external carotid art...

Embodiment 2

[0039] Example 2. Detection of the degree of cerebral edema

[0040] The SD rats were randomly divided into four groups, 18 in each group, respectively sham group, SAH group, OD(2.5) treatment group and OD(5) treatment group, according to the model preparation method and administration regimen treatment in Example 1, Rats in each group were anesthetized with 10% chloral hydrate 48 hours after SAH, and the whole brain was removed by craniotomy. The whole brain was cut out and quickly put on a pre-weighed tin foil for weighing. The weight minus the tin foil weight was the wet weight W1. Then put it in an oven and bake it at 110°C for 72 hours, then weigh it again. The weight minus the tin foil is the dry weight W2, and the cerebral edema index can be obtained by the following formula. Cerebral edema index=[(W1-W2) / W1]×100%. Experimental results such as figure 1 showed that there was a significant difference in brain tissue water content between SAH group and sham group (***P<...

Embodiment 3

[0041] Example 3. Calculation of subarachnoid residual blood volume in each group after subarachnoid hemorrhage

[0042] The SD rats were randomly divided into four groups, 18 in each group, respectively sham group, SAH group, OD(2.5) treatment group and OD(5) treatment group, according to the model preparation method and administration regimen treatment in Example 1, Rats in each group were anesthetized with 10% chloral hydrate 48 h after SAH, and the whole brain was obtained by craniotomy. Take pictures with a high-resolution camera, and observe the bleeding volume of the brain surface, circle of Willis and basilar artery (refer to figure 2 example for scoring). The basal pool is divided into six parts (eg figure 2 A), each part is scored from 0 to 3 points according to the amount of bleeding - 0 points: no bleeding in the inferior cavity; 1 point: a small amount of blood in the inferior cavity; 2 points: moderate blood in discernible blood vessels; 3 Points: The entire...

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Abstract

The invention discloses an application of oldenlandia diffusa, which means that oldenlandia diffusa is used as a medicine for treating subarachnoid hemorrhage. According to the invention, animal model experiments verify that oldenlandia diffusa can alleviate the degree of encephaledema caused by subarachnoid hemorrhage, promote absorption of aneurysmal subarachnoid residual blood, reduce the degree of damage of the blood brain barrier, alleviate the degree of spasm of the base artery blood vessel of the brain and improve the neurological score and the like. By improving the several clinical indexes to further protect the brain tissues, the oldenlandia diffusa has a remarkable treatment effect on subarachnoid hemorrhage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Hedyotis diffusa as a medicine for treating subarachnoid hemorrhage. Background technique [0002] Hedyotis diffusa is the whole herb of Rubiaceae Hedyotis diffusa, which was first recorded in "Famous Doctors", and is also known as Hedyotis diffusa, Hedyotis diffusa, Dwarf-legged Hedyotis diffusa, L. chinensis, Snakehead, Crane's tongue Agave grass, Agave grass, etc. are the types of medicinal materials recorded in Appendix III of the 2010 edition of "Chinese Pharmacopoeia". Previously, they were mostly included in the local medicinal material standards, and they are commonly used Chinese medicinal materials in my country. It is cold in nature, bitter in taste, sweet in taste, and has the effects of returning to the heart, liver, and spleen. Pharmacological studies have shown that the drug has anti-tumor, anti-inflammatory, anti-bacterial, and immune-enhancing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/748A61P9/10
Inventor 李晓明梁国标张婷婷苏静缘
Owner GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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