Application of strictosamide

A technology for isovinposide lactam and periwinkle, which is applied in the field of isovinposide lactam as a preparation of therapeutic drugs, can solve unseen problems and the like, and achieve the effect of reducing the degree of cerebral edema

Active Publication Date: 2017-05-17
GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the literature and reports of medicines and reagents made with it as the active ingredient, there is no record of its application as a drug for the preparation of subarachnoid hemorrhage

Method used

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  • Application of strictosamide
  • Application of strictosamide
  • Application of strictosamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1. Making and administration scheme of subarachnoid hemorrhage rat model

[0034] The subarachnoid hemorrhage model in rats was established by internal carotid artery puncture, and healthy adult male SD rats with a body weight of 250-300 g were taken. Anesthetized with 10% chloral hydrate (3.5ml / kg) intraperitoneally and fixed in supine position. The head and limbs were fixed, the skin was prepared and disinfected at the front of the neck, a median neck incision was taken, and the right common carotid artery (CCA), external carotid artery (ECA) and internal carotid artery (internal carotid artery) were exposed by blunt dissection. Carotidartery, ICA) ligation cuts off the anastomotic branch between the ECA and the ICA, ligates the ECA and cuts and straightens it so that it is in line with the ICA. Take a 3-0 single-strand nylon thread (diameter 0.261mm) to sharpen the head end, mark the 20mm and 22mm at the end of the thread, and insert the nylon thread from...

Embodiment 2

[0036] Example 2. Detection of the degree of cerebral edema

[0037] According to the model preparation method and the treatment plan in Example 1, the rats in each group were anesthetized with 10% chloral hydrate 48 hours after the model was established, and the whole brain was obtained by craniotomy. Weigh it. Subtract the weight of the tin foil to get the wet weight W1. Then put it in the oven and bake it at 110°C for 72 hours, then weigh it again. Subtract the weight of the tin foil to get the dry weight W2. The cerebral edema index can be used obtained by the above formula. Cerebral edema index=[(W1-W2) / W1]×100%.

[0038] Experimental results such as figure 1 As shown in the comparison of the mean ± standard deviation of the degree of brain edema (Brain water content) in the four groups, there is a significant difference in the water content of the brain tissue between the SAH group and the sham group in the right hemisphere (R.H.), that is, the affected side, (**P <0....

Embodiment 3

[0039] Example 3. Comparison of residual blood volume in the subarachnoid space of each group

[0040] According to the model preparation method and administration regimen in Example 1, the rats in each group were anesthetized with 10% chloral hydrate 48 h after modeling, and the whole brain was taken by craniotomy to take pictures, as figure 2 As indicated, the amount of bleeding in each area such as the circle of Willis on the brain surface and the basilar artery was observed and scored. The basal pool is divided into six parts, such as figure 2 Each part is scored from 0 to 3 points according to the amount of bleeding—0 points: no bleeding in the inferior cavity; 1 point: a small amount of blood in the inferior cavity; 2 points: moderate blood in discernible vessels; 3 Points: The entire vessel is covered with a large amount of blood (such as figure 2 Parts B and C of this document). Scoring system for the aorta in the basal cisterns: the anterior cerebral artery (ACA...

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Abstract

The invention provides an application of strictosamide in preparing medicaments for treating subarachnoid hemorrhage, which solves the problem that the medicaments for conventional treatment of subarachnoid hemorrhage are in shortage. The strictosamide has the following advantages and positive effects: strictosamide can markedly reduce the degree of encephaledema caused by subarachnoid hemorrhage, reduce the amount of residual blood in subarachnoid cavity, reduce the level of destruction of the blood brain barrier, reduce the degree of cerebral basilar artery vasospasm and increase the nerve function score. Through the improvement of the above clinical indicators, the prognoses of patients are improved, and the therapeutic action on subarachnoid hemorrhage is remarkable.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of vinblastam as a preparation of therapeutic medicine. Background technique [0002] Subarachnoid hemorrhage (SAH) is divided into primary and secondary. Primary subarachnoid hemorrhage is caused by rupture and bleeding of blood vessels on the surface of the brain and at the base of the brain, and blood flows directly into the subarachnoid space, also known as spontaneous SAH. Secondary SAH was defined as cerebral parenchymal or ventricular hemorrhage, traumatic subdural or epidural hemorrhage flowing into the subarachnoid space. The most common causes of primary subarachnoid hemorrhage are congenital intracranial aneurysms and vascular malformations, with a mortality rate as high as 32%-67%, of which aneurysmal SAH accounts for more than 85%. When SAH occurs, patients show increased intracranial pressure, decreased cerebral blood flow, decreased cerebral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P25/00A61P7/04A61P9/10A61K36/74
CPCA61K31/706A61K36/74
Inventor 李晓明
Owner GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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