Application of compound donkey-hide gelatin pulp in preparing drug for prevention or treatment of human granulocytic anaplasmosis

A technology of compound donkey-hide gelatin and granulocytes, which can be applied in the directions of drug combination, anti-infective drug, and pharmaceutical formulation, etc., can solve the problem that there is no report on the pharmacological effect of compound donkey-hide gelatin.

Active Publication Date: 2014-09-24
SHAN DONG DONG E E JIAO
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Problems solved by technology

[0007] And so far, there is no report on the pharmacological effects of compound...

Method used

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  • Application of compound donkey-hide gelatin pulp in preparing drug for prevention or treatment of human granulocytic anaplasmosis
  • Application of compound donkey-hide gelatin pulp in preparing drug for prevention or treatment of human granulocytic anaplasmosis
  • Application of compound donkey-hide gelatin pulp in preparing drug for prevention or treatment of human granulocytic anaplasmosis

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experiment example 1

[0019] Experimental Example 1: Observation on the curative effect of compound donkey-hide gelatin on blood test recovery in patients with human granulocytic anaplasmosis

[0020] 1. Experimental data

[0021] The 39 patients with human granulocytic anaplasmosis were all hospitalized in Tai'an Central Hospital, Shandong Province from September 2010 to October 2011. All patients were drawn for blood routine and blood biochemical examinations, serum and pathogenic tests. Diagnosis according to the diagnostic criteria in the "Diagnosis and Treatment Program for Human Granulocytic Anaplasmosis (Trial)": 36 confirmed cases and 3 suspected cases; all patients developed symptoms 1-2 weeks after tick bites (average 9 days); 18 of them were males , 21 females; aged 22-72 years, average 48.2 years; mostly acute onset, mainly manifested as persistent high fever (100%), body temperature at 38.5-39.5°C, fatigue (100%), general malaise (95%), Muscle aches (95%), cough (41%), headache (46%),...

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Abstract

The invention relates to an application of a compound donkey-hide gelatin pulp in preparing a drug for prevention or treatment of human granulocytic anaplasmosis, and a pharmaceutical composition composed of the compound donkey-hide gelatin pulp with an effective amount in prevention or treatment and a pharmaceutical acceptable carrier and used for prevention or treatment of human granulocytic anaplasmosis. A lot of experiments disclose that the compound donkey-hide gelatin pulp can effectively reduce the using time for removing fever, subsiding hyperemia, subsiding exudation and stopping mucocutaneous hemorrhage, and obviously shortens the normalization time of platelets, leukocytes, urea nitrogen, creatinine and glutamic-pyruvic transaminase.

Description

technical field [0001] The invention relates to a new application of compound donkey-hide gelatin, in particular to the application of the compound donkey-hide gelatin in the preparation of medicines for preventing or treating human granulocytic anaplasmosis, and belongs to the field of traditional Chinese medicines. Background technique [0002] Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum (Anaplasma phagocytophilum) infecting human peripheral blood neutrophils, mainly characterized by fever accompanied by leukopenia, thrombocytopenia, and multiple organ dysfunction Clinically manifested tick-borne disease. The disease is an intracellular parasite that is mainly transmitted through the bite of ticks (also called ticks). The incubation period is 1-2 weeks. Most of them have acute onset and persistent high fever, which can reach above 40°C. The main clinical manifestations are general malaise, fatigue, headache, muscle aches, nausea, vomiting...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P33/14A61K35/36
CPCY02A50/30
Inventor 秦玉峰尤金花周祥山田守生张淹张路史兆松朱海芳
Owner SHAN DONG DONG E E JIAO
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