Antimicrobial composition
An antimicrobial, composition technology, applied in the direction of drug combinations, active ingredients of hydroxyl compounds, chemicals used for biological control, etc., can solve problems such as corrosion, odor and irritation or photosensitivity
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Embodiment 1
[0175] Example 1: Evaluation of Antimicrobial Efficacy
[0176] Material
[0177] Both p-menthenol and comparative compounds were purchased as fine chemicals from suppliers such as Sigma Aldrich, Alfa Aesar and TCI Fine Chemicals. 2-(4-Methylcyclohex-3-enyl)propan-1-ol was obtained in 97% purity as about 67% ( R )-2-(( R )-4-methylcyclohex-3-en-1-yl)propan-1-ol and about 33% ( R )-2-(( S )-4-methylcyclohex-3-en-1-yl)propan-1-ol mixtures.
[0178] The synthesis of cis- and trans-caprimenthol followed a literature route based on previous literature [K. Winska, A. Grudniewska, A. Chojnacka, A. Bialonska, and C. Wawrzenczyk, Tetrahedron: Asymmetry , 2010, Volume 21 Issue (6), pp. 670-678; S. Serra, E. Brenna, C. Fuganti and F. Maggioni, Tetrahedron: Asymmetry , Volume 14, 2003, pp. 3313–3319]. Lithium aluminum hydride (1.25 g, 32.85 mmol) was suspended in diethyl ether (40 mL) and cooled to 0 °C in an ice / salt bath. Piperonone (5 g, 32.85 mmol) in anhydrous diethyl eth...
Embodiment 2
[0241]In this example, a number of Combination of different chemicals. Each material was obtained in the same manner as in Example 1. Synergy experiments were performed using standard microtiter plate assays with phosphate buffered saline containing 35% dipropylene glycol (DPG). High-resolution MBC was determined by adding various amounts of microbicide to an array of microtiter plates and performing 10-fold serial dilutions using an automated liquid handling system to obtain a series of endpoints ranging from 0.002% to 1% of the test compound. MBC plates were inoculated one column at a time with the test microorganisms. An aliquot of the inoculated well was transferred at 15 seconds to a plate containing neutralizer (D / E Neutralizing Broth), mixed and held for 5 minutes, then transferred to a plate containing Tryptic Casein Soy Broth ( TSB) growth plate. TSB plates were incubated at 37°C and read for presence / absence of growth at 24 hours. The lowest level of the assay t...
Embodiment 3
[0251] Example 3: Automated Assessment of Potency in Surfactant Bases
[0252] Sample Preparation
[0253] In these examples, the efficacy of the combination of thymol and p-menthenol was tested in a surfactant cleaning formulation comprising 2.85% sodium cocoyl glycinate and 1.85% sodium lauroamphoacetate. This corresponds to a use dilution of a typical neat formulation containing 5.7% cocoyl glycinate and 3.7% sodium lauroamphoacetate with 50% water during hand washing. Solutions were prepared such that the concentrations of the surfactant components and test actives were 1.1 times the final desired concentration to allow for dilution with the bacterial inoculum in the test. The solution was adjusted to pH 10.0 by manual dropwise addition of sodium hydroxide solution, as measured with a pH meter at ambient temperature. Solutions of thymol and / or p-menthenol were prepared up to 24 hours before testing. The same thymol and p-menthenol as in Example 1 were used.
[0254] ...
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