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Contraception medicine preparation for females

A technology of contraceptive drugs and preparations, applied in the field of medicine, can solve problems such as impact, excessive bleeding, endocrine disorders, etc., and achieve the effects of easy use, avoiding early pregnancy reactions, and low cost

Inactive Publication Date: 2014-11-05
崔银方
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although oral hormonal contraceptives are more convenient, they affect female endocrine and easily lead to endocrine disorders, resulting in many side effects, and the contraceptive effect is not very satisfactory; intracavitary placement of contraceptive rings can lead to heavy bleeding during menstruation, and easy Cause infection; although ligation is completely contraceptive, it is impossible to reproduce after sterilization
That is, none of the above-mentioned contraceptive measures can satisfy the conditions of being effective, safe, low-cost, and convenient to use at the same time.

Method used

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  • Contraception medicine preparation for females

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of Extract

[0015] Weigh 200g of golden kidney and 500g of Guoshanqing, mix them, pulverize them with a pulverizer, sieve them, add 8L of ethanol solution with a volume concentration of 70%, heat and decoct, reflux extraction for 2 hours, extract 3 times in total, combine filtrates, 4 layers Filter through gauze, recover ethanol under reduced pressure until there is no alcohol smell, continue to concentrate, freeze-dry, pulverize, and pass through a 100-mesh sieve to obtain the extract.

Embodiment 2

[0016] Example 2 Preparation of sugar-coated tablets

[0017] Extract 8g,

[0018] Lactose 60g,

[0019] Mannitol 50g,

[0020] Appropriate amount of starch slurry,

[0021] Croscarmellose Sodium 10g,

[0022] Magnesium Stearate 2g.

[0023] Preparation process: Weigh 8g of the traditional Chinese medicine extract prepared in Example 1, and 60g of lactose, 50g of mannitol and 10g of croscarmellose sodium in the prescribed amount are respectively passed through a 100-mesh sieve, mixed evenly, and prepared after adding an appropriate amount of starch slurry Soft material, pass through a 20-mesh sieve to make wet granules, fully dry the wet granules at 55°C to obtain dry granules; mix the obtained dry granules with magnesium stearate, press 1000 tablets, and then coat with sugar.

Embodiment 3

[0024] Example 3 Contraceptive Experimental Research of Chinese Medicine on Mice

[0025] Vaginal plug is a white serous substance formed by some rodents immediately after mating, which is blocked in the cavity from the vagina to the cervix. It is a sign to check whether the mating has been successful. It is the product of the coagulation of the secretions of the seminal vesicles and coagulation glands of male mice in the vagina. Mice are generally formed within 4-5 minutes after mating. Large pessaries can protrude from the vaginal opening, while small ones can be found inside the vagina or cervix, which can only be seen by opening the vaginal opening. The vaginal plug generally softens gradually 1 hour after mating, and falls off after 16-24 hours. But there are also only 4-5h, and the most can exist for more than 48h. During the reproductive process, the fertilized egg undergoes implantation, differentiation and other processes in the mother's uterus, and finally develop...

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PUM

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Abstract

The invention discloses a contraception medicine preparation for females. The preparation is prepared from active components and pharmaceutically acceptable auxiliary materials, wherein the active components comprise the following traditional Chinese medicinal materials in parts by weight: 15-25 parts of chrysosplenium sinicum and 42-60 parts of reinwardtia trigyna. The contraception medicine preparation disclosed by the invention is applied to contraception by using pure traditional Chinese medicines, so that various side effects caused by western medicines for contraception are avoided, the requirements of contraceptives are met, and meanwhile the requirements of effectiveness, safety, low cost, convenience in use and the like are met.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a contraceptive drug preparation for women. Background technique [0002] At present, commonly used contraceptive measures include: (1) hormonal contraceptives; (2) placement of contraceptive rings in the uterine cavity; (3) ligation. Although oral hormonal contraceptives are more convenient, they affect female endocrine and easily lead to endocrine disorders, resulting in many side effects, and the contraceptive effect is not very satisfactory; intracavitary placement of contraceptive rings can lead to heavy bleeding during menstruation, and easy Cause infection; although ligation is completely contraceptive, it is impossible to have children after sterilization. That is, the above-mentioned contraceptive measures cannot simultaneously satisfy conditions such as effectiveness, safety, low cost, and ease of use. Contents of the invention [0003] In view of the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/55A61P15/18A61K36/185
Inventor 刘学键
Owner 崔银方
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