Application of adenosine compound in preparation of drugs for prevention and treatment of stress disorders

An adenosine compound, stress disorder technology, applied in the field of medicine, can solve the problems of decreased learning and memory ability, stress disorder and related diseases that have not been seen in WS070133 and similar structural compounds

Active Publication Date: 2014-12-03
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (3) Various forms of emotional and physiological arousal and sleep disorders are the most common, and the ability of learning and memory declines
[0010] Up to now, the

Method used

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  • Application of adenosine compound in preparation of drugs for prevention and treatment of stress disorders
  • Application of adenosine compound in preparation of drugs for prevention and treatment of stress disorders
  • Application of adenosine compound in preparation of drugs for prevention and treatment of stress disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Effect of WS070133 in PTSD Mouse Conditioned Electric Shock Model

[0037] 1. Main method

[0038] 1. Experimental device:

[0039] Mouse elevated plus maze (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences).

[0040] Mouse opening device (Shanghai Yishu Information Technology Co., Ltd.).

[0041] YLS-9A Physiological and Pharmacological Electronic Stimulator (Shandong Jinan Yiyan Technology Development Co., Ltd.)

[0042] Mouse electric shock box (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences)

[0043] Mouse jumping box / avoidance box (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences)

[0044] 2. Experimental animals:

[0045] 60 SPF-grade ICR healthy male mice were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and the animal certificate number was SCXK (Beijing) 2009-0007. The initial weight is 12-14g, 10 in each group. Room temperat...

Embodiment 2

[0067] Example 2: Effect of WS070133 in PTSD mouse compound stress model

[0068] 1. Main method

[0069] 1. Experimental device:

[0070] Mouse elevated plus maze (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences).

[0071] Mouse opening device (Shanghai Yishu Information Technology Co., Ltd.).

[0072] YLS-9A Physiological and Pharmacological Electronic Stimulator (Shandong Jinan Yiyan Technology Development Co., Ltd.)

[0073] Mouse electric shock box (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences).

[0074] Mouse water maze (developed by Institute of Materia Medica, Chinese Academy of Medical Sciences)

[0075] Mouse fixation cylinder (Shandong Jinan Yiyan Technology Development Co., Ltd.)

[0076] 2. Experimental animals:

[0077] Seventy-two clean-grade Kunming male mice were provided by Beijing Huafukang Biotechnology Co., Ltd., license number: SCXK (Beijing) 2009-0007. The initial weight is 12-14g, 12 ...

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PUM

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Abstract

The invention discloses application of an adenosine compound WS070133 shown as formula I in preparation of products for prevention or treatment of stress disorders. The stress disorders and related diseases include acute stress disorder, posttraumatic stress disorder, adjustment disorder and phobia, anxiety, mania, bipolar disorder and other diseases. Oral administration of WS070133 on posttraumatic stress disorder model animals shows that the adenosine compound has the effects of lowering animal stress level, reducing fear, anxiety like symptoms and learning and memory impairment. Study also shows that WS070133 can lower the corticosterone level and excitatory amino acid content, reduce apoptosis of neurons and has a regulation effect on related protein molecules. WS070133 has the advantages of low toxicity, no dependence, metabolic and addiction, quick metabolic clearance and no residual effect, etc., thus havaing good application and development prospects. (formula I).

Description

technical field [0001] The invention relates to the application of an adenosine compound in stress disorder and related diseases, in particular to the application of WS070133 and its physiologically acceptable salt in the preparation of drugs for preventing or treating post-traumatic stress disorder, belonging to the technical field of medicine . technical background [0002] Stress disorders and related disorders include acute stress disorder, post-traumatic stress disorder, adjustment disorder and phobias, anxiety disorders, mania, and bipolar disorder. Posttraumatic stress disorder (PTSD), also known as delayed psychogenic reaction (delayed psychogenic reaction), is a mental disorder caused by traumatic events, leading to PTSD events, is a person experienced or witnessed Life-threatening events, including natural disasters and man-made disasters, such as earthquakes, natural disasters, wars, serious accidents, violent crimes, etc. Its incidence rate is high, which bring...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A23L1/29A61P43/00A61P25/22A61P25/24A61P25/18A23L33/00
Inventor 杜冠华吴松黄中麟白晓宇郝玲花
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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