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A single-scan method for obtaining two-dimensional j-decomposition spectrum of magnetic resonance

A magnetic resonance and single-scan technology, which is applied in the directions of using nuclear magnetic resonance spectrum for measurement, magnetic resonance measurement, and magnetic variable measurement, can solve the problems of low signal-to-noise ratio, difficult experiment, poor resolution, etc., and achieve high-resolution Noise ratio and resolution, easy operation, time-shortening effects

Inactive Publication Date: 2017-10-31
XIAMEN UNIV
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Problems solved by technology

While greatly shortening the multidimensional spectrum sampling time, this method also has many defects, such as complex pulse sequences, difficult experiments, high requirements for hardware, poor resolution, low signal-to-noise ratio, etc.

Method used

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  • A single-scan method for obtaining two-dimensional j-decomposition spectrum of magnetic resonance
  • A single-scan method for obtaining two-dimensional j-decomposition spectrum of magnetic resonance
  • A single-scan method for obtaining two-dimensional j-decomposition spectrum of magnetic resonance

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Embodiment 1

[0041] In this embodiment, a Varian 500 MHz magnetic resonance instrument equipped with a three-dimensional gradient field is used, and the sample is pure ethyl 3-bromopropionate. The pulse sequence used has the sampling sequence of the traditional two-dimensional J-decomposition spectrum, such as figure 1 a; A commonly used spatial encoding J-decomposition spectrum sampling sequence, such as figure 1 b; and the present invention provides a single-scan J-decomposition spectrum sampling sequence, such as figure 1 c.

[0042] A method for single-scan acquisition of magnetic resonance two-dimensional J-decomposition spectrum, mainly comprising the following steps:

[0043] 1) Determine the 90-degree and 180-degree pulse width of the sample to be tested;

[0044] 2) Use the measured 90-degree pulse to rotate the magnetization vector of the sample from the Z direction to the XY plane, and repeat the sampling module of "sampling + the 180-degree pulse" 2*N times; where N is J- D...

Embodiment 2

[0052] This embodiment uses a Varian Varian 500MHz magnetic resonance instrument equipped with a three-dimensional gradient field, and the sample is a mixed sample made of ethyl 3-bromopropionate, pyridine and dihydrofuran at a volume ratio of 1:1:1

[0053] Measure the width of the 90-degree and 180-degree hard pulses of the sample, respectively. The spectral widths required to determine the indirect dimension F1 and direct dimension F2 of the two-dimensional J-decomposition spectrum of the sample are 50Hz and 5000Hz, respectively. For the single-scan J-decomposition spectrum sampling sequence, set the single sampling time Ta=10ms, the number of sampling points N2=50, the number of indirect dimension F1 points N=50, and the execution time of the whole sequence is about 1s.

[0054] refer to image 3 b. image 3 c It can be seen that compared with the results obtained by the single-scan J-decomposition spectrum sampling sequence and the traditional method, the J-coupled spli...

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Abstract

The invention provides a method for acquiring two-dimensional J-resolved spectroscopy of magnetic resonance by single sweeping. Through a module executing 'sampling and 180-degree pulsing' repeatedly after exciting a magnetization vector to an XY plane, data needed for two-dimensional J- resolved spectroscopy can be acquired by only one-time excitation. In order to acquire better resolution on a direct dimension F2 of a spectrogram, raw data are predicted along the direct dimension F2, and signals are attenuated completely. Compared with a traditional method, the method has the advantage that time of experiment is shortened greatly; compared with a previous spatial encoding method, the method is equivalent to the previous method in experimental time, can provide higher signal to noise ratio and resolution, and is simple in sequence and convenient to operate; compared with a one-dimensional spectroscopy method, the method is equivalent to the method in experimental time, but can provide finer J-coupling split peak information. The simple and efficient method plays an important role in metabolite batch testing, organic chemistry reaction and bioassay.

Description

technical field [0001] The invention relates to a method for obtaining a two-dimensional magnetic resonance J-decomposition spectrum, in particular to a method for obtaining a two-dimensional magnetic resonance J-decomposition spectrum with a single scan. Background technique [0002] Two-dimensional J-decomposition spectroscopy is one of the most commonly used two-dimensional spectra in magnetic resonance spectroscopy. It can separate the chemical shift and J-coupling information into two dimensions of the two-dimensional spectrum, so that the structural information of substances can be better analyzed . The conventional sampling method of two-dimensional J-decomposition spectrum (W.P.Aue, J.Karhan and R.R.Ernst, Homonuclear broad band decoupling and two dimensional J-resolved NMR Spectroscopy, The Journal of Chemical Physics, 1976, 64, 4226.) is in the indirect dimension J Based on the coupling evolution, multiple one-dimensional spectra are collected. A two-dimensional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R33/46
Inventor 林雁勤林良杰韦芝良陈忠
Owner XIAMEN UNIV
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